The effect of transferring a poor-quality embryo together with a good-quality embryo on the singleton birth weight: A retrospective cohort study.

Dashti S, Saeideh Dashti, Pejman A, Atefeh Pejman, Tabibnejad N, Nasim Tabibnejad, Mortezanasab M, Maedeh Mortezanasab
International journal of reproductive biomedicine · 2022 · doi:10.18502/ijrm.v20i2.10500 · PMID:35434477 · PMC9002169
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This retrospective cohort study analyzed data from 626 infertile women undergoing IVF or ICSI to determine if transferring one poor-quality embryo alongside a good-quality embryo affects singleton birth weight. The researchers compared neonatal outcomes across groups receiving single good-quality embryos, double good-quality embryos, and a combination of one good-quality and one poor-quality embryo in both fresh and frozen-thawed cycles. Statistical analysis revealed no significant differences in mean birth weight, low birth weight rates, or preterm delivery among the three embryo quality groups after adjusting for confounding variables. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundEmbryo quality may affect birth weight among neonates born through assisted reproductive technology. There are very limited studies assessing the adverse effect of transferring a poor-quality embryo with a good-quality one on neonatal outcomes.ObjectiveThe aim of this study was to evaluate the effect of double embryo transfer (DET) with one good-quality embryo (GQE) plus a poor-quality one on the birth weight of newborns conceived by in vitro fertilization in both fresh and frozen-thawed embryo transfer cycles.Materials and methodsThis study was conducted at Yazd Reproductive Sciences Institute, Yazd, Iran. A total of 626 women were classified into three groups according to the embryo quality: single embryo transfer with a GQE (group A); DET using two GQEs (group B); and DET using one good-quality and one poor-quality embryo (group C). The primary outcome was singleton birth weight which was compared between the three groups among fresh and frozen-embryo transfer cycles. A comparative analysis was also performed regarding the effect of vitrification procedures on neonatal birth weight within each of the three embryo quality-based groups.ResultsThe mean birth weight and the rate of preterm birth were similar between the three groups (p = 0.45 and 0.32, respectively). There were also no significant differences found in the vitrification comparative analysis between and within the groups with regard to birth weight.ConclusionOur results showed that a poor-quality embryo did not have a significant influence on a good-quality one regarding neonatal birth weight when transferred together.
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In conclusion, our results showed that a PQE did not have a significant influence on a GQE regarding neonatal birth weight when transferred together. This study was a retrospective one and naturally a randomized controlled trial would be more persuasive.

Coi Statement

The authors declare that there is no conflict of interest.

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