Role of environmental organochlorinated pollutants in the development of endometriosis.

M G Porpora, Maria Grazia Porpora, S Resta, Serena Resta, Eliana Fuggetta, E Fuggetta, Paola Storelli, P Storelli, F Megiorni, Francesca Megiorni, Lucia Manganaro, L Manganaro, E De Felip
Clinical and experimental obstetrics & gynecology · 2013 · vol. 40(4) , pp. 565–7 · PMID:24597257 · W315591759
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review examines epidemiological studies investigating the link between environmental organochlorinated pollutants and endometriosis, focusing on their potential effects on cytokines, the immune system, hormones, and growth factors.

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Abstract

Endometriosis is a gynecological disease, which involves the growth of endometrial tissue outside the uterine cavity, commonly in the pelvic region. The etiology of the disease is unclear, but multiple factors may contribute to its pathogenesis. Environmental organochlorinated pollutants, particularly dioxins and polychlorinated biphenyls (PCBs), are thought to play a role in the development of this disease; however, the results of clinical trials are discordant, and it is not clear how the effect of exposure to these compounds is linked to endometriosis. Their effects on cytokines, immune system, hormones, and growth factors are thought to increase the risk of endometriosis. The purpose of this review is to provide an overview of epidemiological studies, which have evaluated the relationship between endometriosis and exposure to persistent organochlorinated pollutants.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Environmental Pollutants Hydrocarbons, Chlorinated Dioxins Dioxins Endocrine Disruptors Endometriosis Environmental Pollutants Estrogens Female Humans Hydrocarbons, Chlorinated Immune System Polychlorinated Biphenyls Polychlorinated Biphenyls Progesterone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (13)

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europepmc
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openalex
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License: CC0 · commercial use OK