Sequential danazol/leuprolide acetate therapy for ovarian suppression in an in vitro fertilization patient unresponsive to leuprolide acetate

Juan Balasch, J Balasch, Francisco Fábregues, F Fábregues, Montserrat Creus, M Creus, J A Vanrell, Juan A. Vanrell
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1997 · vol. 11(1) , pp. 21–24 · doi:10.3109/09513599709152312 · PMID:9086335 · W1980763216
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Sequential danazol/leuprolide acetate therapy achieved pituitary-ovarian suppression in an IVF patient unresponsive to leuprolide acetate alone, reducing estradiol levels and demonstrating a viable alternative for ovarian arrest.

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Abstract

We report a case of pituitary-ovarian suppression obtained with sequential danazol/leuprolide acetate administration in a patient undergoing in vitro fertilization and unresponsive to leuprolide acetate alone and sequential oral contraceptive-leuprolide acetate therapy. Leuprolide acetate (1 mg daily subcutaneously) was administered after 5 weeks of danazol treatment (800 mg daily) while the latter was maintained for 1 additional week. Ovarian activity was assessed by transvaginal ultrasonography and serum estradiol determination. After 5 weeks of danazol therapy, ovarian arrest was obtained despite the fact that gonadotropin serum levels did not change relative to basal values. Leuprolide acetate injection for 14 days was associated with a decrease in serum concentrations of follicle-stimulating hormone and luteinizing hormone and a further decrease of the estradiol level. We conclude that sequential danazol/leuprolide acetate therapy is a useful alternative for obtaining ovarian arrest in patients unresponsive to leuprolide acetate alone.

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MeSH descriptors

Danazol Estrogen Antagonists Fertilization in Vitro Leuprolide Adult Contraceptives, Oral Contraceptives, Oral Danazol Danazol Embryo Transfer Estradiol Estradiol Estrogen Antagonists Estrogen Antagonists Ethinyl Estradiol Ethinyl Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans

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