Sequential danazol/leuprolide acetate therapy for ovarian suppression in anin vitrofertilization patient unresponsive to leuprolide acetate

Juan Balasch; Francisco Fábregues; Montserrat Creus; Juan A. Vanrell

doi:10.3109/09513599709152312

Sequential danazol/leuprolide acetate therapy for ovarian suppression in anin vitrofertilization patient unresponsive to leuprolide acetate

Juan Balasch, Francisco Fábregues, Montserrat Creus, Juan A. Vanrell

In: Gynecological Endocrinology · 1997 · vol. 11(1) , pp. 21–24 · doi:10.3109/09513599709152312 · PMID:9086335 · W1980763216

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Sequential danazol/leuprolide acetate therapy achieved pituitary-ovarian suppression in an IVF patient unresponsive to leuprolide acetate alone, reducing estradiol levels and demonstrating a viable alternative for ovarian arrest.

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Abstract

We report a case of pituitary-ovarian suppression obtained with sequential danazol/leuprolide acetate administration in a patient undergoing in vitro fertilization and unresponsive to leuprolide acetate alone and sequential oral contraceptive-leuprolide acetate therapy. Leuprolide acetate (1 mg daily subcutaneously) was administered after 5 weeks of danazol treatment (800 mg daily) while the latter was maintained for 1 additional week. Ovarian activity was assessed by transvaginal ultrasonography and serum estradiol determination. After 5 weeks of danazol therapy, ovarian arrest was obtained despite the fact that gonadotropin serum levels did not change relative to basal values. Leuprolide acetate injection for 14 days was associated with a decrease in serum concentrations of follicle-stimulating hormone and luteinizing hormone and a further decrease of the estradiol level. We conclude that sequential danazol/leuprolide acetate therapy is a useful alternative for obtaining ovarian arrest in patients unresponsive to leuprolide acetate alone.

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Cites (1)

Danazol-induced Pseudomenopause in the Management of Endometriosis 1988

References (8)

Danazol-induced Pseudomenopause in the Management of Endometriosis via openalex
doi:10.1093/oxfordjournals.humrep.a137832 via openalex
W580619127 via openalex
doi:10.1016/s0015-0282(16)56839-3 via openalex
doi:10.1016/0002-9378(81)90611-6 via openalex
doi:10.1016/s0015-0282(16)55448-x via openalex
doi:10.1016/s0015-0282(16)56595-9 via openalex
doi:10.1016/s0015-0282(16)54548-8 via openalex

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[1] Danazol-induced Pseudomenopause in the Management of Endometriosis 1988