Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology

Cullberg G; G Cullberg; Göran Cullberg

doi:10.1016/0010-7824(84)90080-5

Androgenic, anabolic, estrogenic and antiestrogenic effects of desogestrel and lynestrenol: effects on serum proteins and vaginal cytology

Cullberg G, G Cullberg, Göran Cullberg

Contraception · 1984 · vol. 30(1) , pp. 73–9 · doi:10.1016/0010-7824(84)90080-5 · PMID:6236952

RCT OA: closed public-domain-us

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In women with pelvic endometriosis, desogestrel and lynestrenol suppressed SHBG and vaginal cytology maturation values without estrogenic effects, while lynestrenol showed weak androgenic activity.

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Abstract

Eight healthy (apart from pelvic endometriosis) women were given daily doses of 0.125, 0.250 and 0.500 mg of desogestrel or 5 mg of lynestrenol orally in a randomized order. Duration of each treatment was 6 weeks. Serum was analyzed for sex hormone binding globulin (SHBG), ceruloplasmin, cortisol binding globulin (CBG), thyroxine binding globulin (TBG) and prealbumin using an electroimmunoassay. Serum 17 beta-estradiol (E2) and testosterone (T) were analyzed by radioimmunoassay. Vaginal cytology was studied using the maturation value (MV). E2 levels were depressed by desogestrel and lynestrenol apart from values in two women after 0.125 mg desogestrel. T concentration was suppressed by desogestrel but not by lynestrenol. SHBG concentration and MV were dose-dependently suppressed indicating an antiestrogenic or possibly androgenic effect of desogestrel and lynestrenol. No androgenic or anabolic effects of desogestrel were however seen, e.g. suppression of TBG content or increase in prealbumin levels. For lynestrenol, however, a small but significant increase in prealbumin concentration indicated a weak androgenic/anabolic effect. No estrogenic effects were seen, e.g. increases in ceruloplasmin, CBG levels or in elevations of MV. A depressed SHBG production ability in the hepatocytes during treatment with 19-nortestosterone derivatives is postulated, possibly due to competitive receptor binding.

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Condition tags

endometriosis

MeSH descriptors

Blood Proteins Estradiol Lynestrenol Lynestrenol Norpregnenes Norpregnenes Progesterone Congeners Progesterone Congeners Testosterone Vagina Adult Adult Blood Proteins Blood Proteins Carrier Proteins Carrier Proteins Carrier Proteins Ceruloplasmin Ceruloplasmin Ceruloplasmin

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens 1979

References (12)

A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens via crossref
doi:10.3109/00016348209155359 via crossref
doi:10.1210/jcem-32-2-232 via crossref
doi:10.1111/j.1365-2265.1979.tb03031.x via crossref
doi:10.1530/acta.0.0760159 via crossref
doi:10.1016/s0002-9378(16)32379-1 via crossref
doi:10.1016/0010-7824(77)90079-8 via crossref
doi:10.1016/s0010-7824(75)80019-9 via crossref
doi:10.1111/j.1471-0528.1980.tb04571.x via crossref
doi:10.1016/0022-4731(81)90171-0 via crossref
doi:10.3109/00016348209155355 via crossref
doi:10.1210/jcem-52-1-138 via crossref

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[1] A comparison of plasma protein changes induced by danazol, pregnancy, and estrogens 1979