[Synthesis of danazol derivatives and steroidal-3-oxo-2 alpha-carbonitriles]
Lab / animal
OA: closed
CC0
AI-generated summary
Researchers synthesized danazol analogues, specifically steroidal-3-oxo-2α-carbonitriles and isoxazoles, finding that derivative IIIc exhibited twice the progesterone receptor binding activity of danazol.
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Abstract
Synthesis of danazol analogues involved transformation of 3-ketosteroids (Ⅰa～c) into 2-hydroxymethylene steroids (Ⅱa～c) and subsequent cyclization to steroidal (2, 3 d) isoxazoles (Ⅲa～c), Further treatment with sodium methoxide gave the corresponding steroidal-3-oxo-2α-carbonitriles (Ⅳa～c). The binding ability of (Ⅲa～c) and (Ⅳa～c) to progesterone receptor were examined and (Ⅲc) was found to be two times as active as danazol
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- openalex
- last seen: 2026-05-10T11:08:06.696558+00:00
- pubmed
- last seen: 2026-10-08T21:26:18.239251+00:00
License: CC0
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