Yao xue xue bao = Acta pharmaceutica Sinica

Endometriosis, an oestrogen-dependent disorder, is related to inflammation, p38 Mitogen activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions …

A sensitive, specific and rapid RP-HPLC method was developed for simultaneously determining a synthetic steroid drug danazol (Ⅰ) and its metabolites 2-hydroxymethylethisterone (Ⅱ) and ethisterone (Ⅲ). A column packed with YWG-C18, 10 μm and…

Synthesis of danazol analogues involved transformation of 3-ketosteroids (Ⅰa～c) into 2-hydroxymethylene steroids (Ⅱa～c) and subsequent cyclization to steroidal (2, 3 d) isoxazoles (Ⅲa～c), Further treatment with sodium methoxide gave the cor…

Gossypol has been employed in gynecologic clinics for the treatment of endometriosis and functional uterine bleedings with encouraging results. In the present communication the effects of gossypol on the uterus and ovary were studied both e…