Implantation rates of embryos generated from slow cooled human oocytes from young women are comparable to those of fresh and frozen embryos from the same age group

Debra A. Gook; Gook DA; David H. Edgar; Edgar DH

doi:10.1007/s10815-011-9678-6

Implantation rates of embryos generated from slow cooled human oocytes from young women are comparable to those of fresh and frozen embryos from the same age group

Debra A. Gook, Gook DA, David H. Edgar, Edgar DH

Journal of assisted reproduction and genetics · 2011 · vol. 28(12) , pp. 1171–6 · doi:10.1007/s10815-011-9678-6 · PMID:22127676 · PMC3241837

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This study found that slow-cooled human oocytes from young women achieve fertilization and implantation rates comparable to fresh oocytes and cryopreserved embryos, challenging previous reports of reduced clinical efficiency.

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Abstract

Previous reports of slow cooling of human mature oocytes have shown a reduced clinical efficiency relative to fresh oocytes. This study reports that equivalent fertilization and implantation rates to those obtained using fresh oocytes and cryopreserved embryos can be achieved with human mature oocytes dehydrated in 1.5 M propanediol and 0.2 M sucrose at 37°C and cryopreserved using slow cooling rates.

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MeSH descriptors

Embryo Implantation Embryo, Mammalian Oocytes Adult Cryopreservation Cryopreservation Cryoprotective Agents Cryoprotective Agents Embryo Implantation Embryo, Mammalian Embryo, Mammalian Female Humans Oocytes Oocytes Propylene Glycol Propylene Glycol Sucrose Sucrose

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Cites (1)

Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program 2010

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[1] Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program 2010