Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males.

| Volume 15, Issue 5 (September 2013) 15, 626–629; 10.1038/aja.2013.10 Body mass index is not associated with sperm–zona pellucida binding ability in subfertile males Nathalie Sermondade1,2, Charlotte Dupont1,2,3, Céline Faure1,2, Marouane Boubaya4, Isabelle Cédrin-Durnerin2,5, Pascale Chavatte-Palmer3, Christophe Sifer1 and Rachel Lévy1,2 1Service d'Histologie-Embryologie-Cytogénétique-Biologie de la Reproduction-CECOS, Hôpital Jean Verdier (AP-HP), HUPSSD, Bondy 93143, France 2INSERM U557; INRA U1125; CNAM EA3200; Univ Paris 13; CRNH IdF, Unité de Recherche en Epidémiologie Nutritionnelle, Bobigny, 93017, France 3INRA, UMR1198 Biologie du Développement et Reproduction, Jouy-en-Josas 78352, France 4Unité de Recherche Clinique, Hôpital Avicenne, Bobigny 93009, France 5Service d'Assistance Médicale à la Procréation, Hôpital Jean Verdier (AP-HP), Bondy 93143, France Correspondence: Dr N Sermondade, ([email protected]) Received 4 November 2012; Revised 24 December 2012; Accepted 20 January 2013 Advance online publication 17 June 2013 | Abstract | | Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index (BMI) and sperm–zona pellucida binding ability assessed according to the zona binding (ZB) test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization (IVF) ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated. Keywords: body mass index (BMI); fertilization ability; obesity; semen quality; zona binding test PDF | PDF | 中文摘要 | | | | | Browse: 5149 | |