Journal of assisted reproduction and genetics

PURPOSE: A reduced fertilization rate is a frustrating condition for patients and embryologists. This study aimed develop a statistical metric, LOW FERTILIZATION, to determine whether a distinct pathological entity underlies reduced fertili…

PURPOSE: Environmental microbiological monitoring is mandatory in IVF laboratories; however, procedure-specific risk assessment across the entire medically assisted reproduction workflow remains limited. This multicenter study, named "SMILE…

PURPOSE: Accurate assessment of oocyte developmental competence remains challenging in IVF, as morphology alone offers limited insight into intrinsic oocyte quality. Emerging evidence indicates that oocyte competence reflects coordinated re…

PURPOSE: To evaluate whether the outcomes and characteristics of a first IVF/ICSI cycle are associated with embryological and clinical outcomes in a subsequent cycle performed within 2 years. METHODS: This retrospective single-center obser…

PURPOSE: To evaluate whether artificial endometrial preparation using hormone replacement therapy (HRT) influences clinical and neonatal outcomes compared with modified natural cycles (mNC) in single euploid vitrified-warmed blastocyst tran…

PURPOSE: To study whether there is a marked interobserver discrepancy in the diagnosis of adenomyosis based on reviewing stored sonographic images of infertile patients? METHODS: Three reproductive endocrinology and infertility specialists…

PURPOSE: To assess whether the endometrial receptivity analysis (ERA) captures receptivity changes attributed to endometrial aging and whether it may be useful for older patients undergoing fertility treatment. METHODS: Retrospective cohor…

PURPOSE: To assess whether specific markers of oxidative stress and DNA damage are expressed at higher levels in primordial follicles of patients with endometriomas compared to age-matched controls. METHODS: A retrospective pilot cohort st…

PURPOSE: Infertility affects 1 in 6 couples, yet male fertility assessments often rely on semen analysis alone, which has limited predictive value for treatment success. This study evaluates an epigenetic tool for assessing sperm quality, a…

PURPOSE: Does fertility preservation (FP) through oocyte cryopreservation provide realistic reproductive opportunities for diminished ovarian reserve (DOR)? Literature suggests cumulative live birth rates of 30-45% with 8-10 oocytes under 3…

OBJECTIVE: To evaluate follicular fluid (FF) SCUBE1 levels as a novel angiogenesis-associated biomarker and investigate its role in reflecting the follicular vascular microenvironment and predicting ovarian response in women undergoing assi…

The mouse embryo assay (MEA) is the standard test used in assisted reproduction to evaluate the toxicity and effectiveness of culture media and consumables. However, the assay has been criticised for its limited sensitivity, inconsistencies…

PURPOSE: To compare live birth rates after in vitro fertilization (IVF) with oocyte donation between women with Turner syndrome and women with premature ovarian insufficiency (POI) of other etiologies and to evaluate the relationships betwe…

BACKGROUND: Abnormal pronuclear formation, including five pronuclei (5PN), is generally considered indicative of abnormal fertilization (e.g., polyspermy or failure of polar body extrusion) and leads to routine embryo discard in many IVF pr…

PURPOSE: The use of in vitro fertilization (IVF) has increased substantially, raising interest in the long-term health outcomes of women undergoing these treatments. OBJECTIVE: To assess the association between conception through autologou…

PURPOSE: This systematic review investigates the relationship between follicular fluid metabolomic profiles and different female infertility conditions, focusing on the molecular alterations associated with each condition. METHODS: A syste…

PURPOSE: To compare live birth rates (LBRs) between mosaic and euploid embryos. METHODS: Retrospective cohort study analyzing frozen mosaic (56) and euploid (819) embryos tested with next generation sequencing, transferred between October …

PURPOSE: Oocyte quality declines with age and metabolic stress, largely due to mitochondrial dysfunction and NAD⁺ depletion. Nicotinamide mononucleotide (NMN), a precursor of NAD⁺, has emerged as a potential intervention to restore cellular…

PURPOSE: Cancer treatments can deplete the ovarian follicle reserve causing infertility and early menopause, with subsequent decline in cardiovascular, cognitive, and overall health. Medical measures to prevent this chemotherapy-induced ova…

PURPOSE: To identify treatment-related factors influencing low oocyte maturation rates in standard ovarian stimulation (OS) cycles and patients' candidates for clinical studies on rescue-IVM. METHODS: Retrospective study including retrieva…

BACKGROUND AND OBJECTIVE: Artificial intelligence (AI) has emerged as a promising tool for clinical decision support in reproductive medicine, yet the performance of general-purpose large language models (LLMs) in predicting in vitro fertil…

PURPOSE: To systematically evaluate the impact of post-thaw culture duration on frozen embryo transfer (FET) outcomes across different embryonic developmental stages. METHODS: We conducted a systematic review and meta-analysis following PR…

PURPOSE: Cancer treatments can deplete the ovarian follicle reserve, causing infertility and early menopause, with subsequent decline in cardiovascular, cognitive, and overall women's health. Medical measures to prevent this chemotherapy-in…

Female reproductive disorders present significant challenges worldwide. Transfer RNA-derived small RNAs (tsRNAs), a structurally diverse class of non-coding RNAs mainly comprising tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), have…

PURPOSE: Endometriosis (EM) is a chronic inflammatory gynecological disorder characterized by ectopic endometrial-like lesions, where aberrant angiogenesis is a hallmark driving lesion establishment and progression. However, the transcripti…