Reproduction & fertility

ABSTRACT: This study aimed to investigate whether an early LH surge during controlled ovarian stimulation (COS) affects pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive technology (ART) a…

ABSTRACT: Endometriosis is a common, inflammatory condition impacting 200 million women and those assigned female at birth, where 25-40% experience infertility. Ovarian endometriosis is known to decrease anti-Müllerian hormone (AMH) levels …

Adenomyosis and endometriosis are two sister diseases that cause menstrual pain and other symptoms. We have previously reported that patients with these conditions have a less active 'calm-and-rest' system and a more active 'stress-and-aler…

ABSTRACT: Decidualization of human endometrial stromal cells (ESCs) precedes the successful implantation of a human embryo. Improper decidualization has been reported in numerous conditions associated with infertility, including endometrios…

ABSTRACT: Chronic endometritis (CE) is a localized inflammatory disorder of the endometrium characterized by plasma cell infiltration, most often identified by CD138 immunostaining. Its diagnosis remains problematic due to the absence of st…

ABSTRACT: Infertile patients initially undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with fresh embryo transfer often lack baseline indications for preimplantation genetic testing for aneuploidy (PGT-A); howe…

AbstractThe objective of this study was to evaluate whether cumulus cell (CC) DNA fragmentation is associated with oocyte yield and the probability of obtaining at least one good-quality day-5 blastocyst in intracytoplasmic sperm injection …

ABSTRACT: Low oocyte retrieval (LOR), defined as oocytes retrieved from <50% of mature follicles, significantly impacts IVF success, especially in patients with diminished ovarian reserve (DOR). Predictive models tailored for this populatio…

ABSTRACT: The endometrium is the primary site of embryo implantation. Cellular senescence within the endometrium can be broadly categorised into normal cyclical senescence and pathological excessive senescence. Normal cyclical senescence oc…

ABSTRACT: Endometriosis, with a global prevalence of approximately 18%, is a chronic condition that significantly impacts patients' quality of life and increases the risk of depression. Despite growing public health concerns, access to heal…

Endometriosis is a chronic pain condition that affects >190 million people worldwide. It is recommended in clinical guidelines to remove the most common type of endometriosis, 'superficial peritoneal endometriosis' (SPE), if it is diagnosed…

ABSTRACT: Oncofertility has emerged as a critical interdisciplinary field addressing the reproductive challenges faced by cancer patients, particularly those undergoing chemotherapy. While chemotherapeutic agents remain indispensable in can…

ABSTRACT: Hydrosalpinx is a chronic pathological manifestation seen in approximately 30% of tubal disease cases. In addition to contributing to infertility and pelvic pain, hydrosalpinx has been associated with early pregnancy loss and redu…

Graphical abstractAbstractPregnancy involves inflammatory processes, and the endometrium is populated by a range of immune cells whose functions depend on pregnancy length, species and placentation type. In eutherians, prolonged embryo-mate…

ABSTRACT: This study aimed to characterize phase-specific dynamics of androstenedione and estradiol across IVF/ICSI treatment, identify predictors of reproductive outcomes, and examine the effects of follicle-stimulating hormone (FSH), IGF1…

AbstractMenopause following cancer treatment is an increasingly recognised component of survivorship yet remains under-addressed in clinical care. The aim of this review was to synthesise current evidence on menopause induced by cancer trea…

ABSTRACT: Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) are thought to arise from distinct yet partially overlapping causes, with a substantial number of cases associated with immune system alterations. We hypothes…

Endometriosis is a condition where tissue similar to the lining of the uterus (endometrium) grows outside the uterus, which can cause severe chronic pelvic pain, limit quality of life, and lead to infertility. In addition to standard medica…

Infertility is defined by the World Health Organization as the inability to achieve pregnancy after one year of regular, unprotected sexual intercourse. Female infertility can result from problems with ovulation, hormone imbalances, endomet…

ABSTRACT: Mammalian oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm-specific phospholipase C zeta (PLCζ). Sperm PLCζ deficiency is linked to male infertility caused by oocyte activation deficiency. …

ABSTRACT: Endometriosis is a chronic inflammatory disease presenting with debilitating symptoms strongly impacting patients' quality of life (QoL). Assessing QoL is crucial for understanding the full patient experience beyond clinical sympt…