JAMA network open

BACKGROUND: Appendiceal adenocarcinoma (AA) is a rare gastrointestinal cancer that frequently presents with peritoneal metastases; the standard of care for resectable peritoneal metastases from AA limited to the peritoneum is cytoreductive …

IMPORTANCE: Premenopausal patients with breast cancer are treated with gonadotropin-releasing hormone agonist (GnRHa) therapy to suppress ovarian function. Therapy requires subcutaneous or intramuscular injection and is routinely administer…

IMPORTANCE: High-quality evidence on cancer occurrence for women who have used medically assisted reproduction (MAR) is required to guide care. OBJECTIVE: To compare cancer incidence in MAR-exposed women with the general population of wome…

IMPORTANCE: Kawasaki disease is a leading cause of acquired heart disease among children in high-income countries, but potential associations between fertility treatments and Kawasaki disease remain unknown, despite both becoming increasing…

IMPORTANCE: As endometrial cancer (EC) incidence rises, particularly among individuals with obesity and metabolic disorders, effective strategies targeting hormonal and metabolic risks are needed. OBJECTIVE: To evaluate EC risk in patients…

IMPORTANCE: Concerns regarding weight changes during hormonal contraceptive use may influence health care-seeking behavior and contraceptive use patterns. While semaglutide use for weight management has increased substantially among women o…

IMPORTANCE: It is critical that women undertaking medically assisted reproductive (MAR) treatment and their clinicians know whether the treatments are associated with an increased risk of hormone-related cancers. OBJECTIVE: To determine th…

IMPORTANCE: Puberty blockers are an established, reversible intervention for central precocious puberty in children and gender dysphoria in adolescents. Despite broad clinical support, these treatments are currently politically contested. …

IMPORTANCE: Excess cryopreserved embryos present financial, logistical, and ethical constraints on patients and fertility clinics that are further complicated by the recently evolving US judicial landscape that may alter the legal status of…

ImportanceTreatments for men seeking fertility care are limited. Antioxidant supplements have been widely studied as a new treatment option, but these studies have had conflicting results.ObjectiveTo assess whether treatment of men seeking …

IMPORTANCE: Medicare is the primary health insurance payer for 1.5 million reproductive-aged women with disabilities, yet it is the only major form of US health insurance that is not required to cover contraceptives for pregnancy prevention…

This survey study examines which dietary modifications or supplements were perceived as beneficial for pain management by individuals with endometriosis.

IMPORTANCE: Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality globally. Although traditional management relies on blood loss quantification, identifying cases resistant to conventional treatment remains challenging…

IMPORTANCE: Despite the availability of effective interventions, fear of cancer recurrence (FCR) remains a prevalent concern among cancer survivors, underscoring the need for approaches that balance accessibility (eg, an online program with…

IMPORTANCE: Medical gaslighting, in which a patient's concerns are dismissed without proper evaluation, has been described anecdotally in vulvovaginal patient care, but has not been quantified. OBJECTIVE: To use a patient-centered instrume…

IMPORTANCE: Multiple studies have identified an association between COVID-19 vaccination and menstrual disturbances. Data on whether menstrual health is impacted by other vaccines are needed to counsel individuals about what to expect and t…

IMPORTANCE: Hormonal contraceptive (HC) use is associated with depression. It is, however, unknown whether this is also true in the postpartum period when women have a heightened depression risk and are routinely offered HC treatment. OBJE…

IMPORTANCE: The emergency department (ED) is a critical point of contact within the health care system and an opportunity to initiate nonpharmacologic migraine treatment. OBJECTIVE: To examine whether progressive muscle relaxation (PMR) sm…

IMPORTANCE: Fertility status is a marker for future health, and infertility has been associated with risk for later cancer and diabetes, but associations with midlife cardiovascular health (CVH) in female individuals remain understudied. O…

IMPORTANCE: Although multiple mechanisms have been proposed to explain the infertility related to endometriosis, there are no conclusive data on the association of endometriosis with endometrial receptivity. The oocyte donation model in ass…

ImportanceIndividuals who use contraceptive pills, patches, and rings must frequently interact with the health care system for continued and consistent use. As options for obtaining these methods expand, better understanding contraceptive u…

IMPORTANCE: Poor ovarian response (POR) to stimulation may impact patients' desire or need to utilize cryopreserved oocytes for family building in the future. These findings, captured by Society for Assisted Reproductive Technology (SART) n…