Reproductive biology and endocrinology : RB&E

BACKGROUND: Endometriosis is a gynecological disorder that affects 190 million reproductive age women worldwide. Laparoscopic surgery is considered the gold standard to diagnose the disease, creating a barrier to diagnosis and leading to lo…

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and have been shown to interfere with the endocrine system, leading to adverse effects on reproductive health. In females, EDC exposure has been linked to menstrual irr…

INTRODUCTION: The effect of endometrial thickness on live birth rates after embryo transfer, and whether there is a threshold below which the chances of live birth decrease, remains unclear. Although the eutopic endometrium in women with en…

BACKGROUND: This retrospective cohort study aimed to evaluate the impact of insulin resistance (IR) on clinical outcomes in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injectio…

BACKGROUND: To investigate whether endometriosis is associated with the risk of incident nonalcoholic fatty liver disease (NAFLD). METHODS: Data were retrieved from Nurses' Health Study II with participants followed up from 1995 to 2017. A…

BACKGROUND: Morphological embryo assessment, time-lapse imaging or PGT-A can prioritize an embryo for transfer in IVF/ICSI cycles. Nevertheless, there remains potential to enhance the efficiency of ART cycles and reduce the time-to-pregnanc…

BACKGROUND: AMH is a dependable indicator of ovarian reserve function and assessment of ovarian responsiveness. The relationship between reduced ovarian reserve and pregnancy loss remains poorly understood and requires further investigation…

BACKGROUND: Uterine contractions, also known as peristalsis, have been shown to affect fertility. However, despite previous studies, most clinicians have not paid sufficient attention to uterine peristalsis. Recent studies have recognised i…

BACKGROUND: Endometriosis is a chronic gynecological disorder affecting approximately 10% of women of reproductive age. It commonly presents with pelvic pain, dysmenorrhea, and infertility, imposing substantial physical, psychological, and …

BACKGROUND: Overweight and obesity-chronic illnesses in which an increase in body fat promotes adipose tissue dysfunction and abnormal fat mass resulting in adverse metabolic, biomechanical, and psychosocial health consequences-negatively i…

OBJECTIVE: This study aimed to investigate the microbiome profile in the cystic fluid of ovarian endometrioma and explore its association with the microbial communities present in the lower and upper reproductive tracts. DESIGN: A microbia…

BACKGROUND: Most methods of ovarian stimulation rely on gonadotropin modulation. However, abnormal anti-Müllerian hormone concentrations are frequent in infertility, suggesting that defects in the gonadotropin-independent period of follicul…

BACKGROUND: Polycystic ovary syndrome (PCOS) and obesity can both disrupt reproductive function. However, the extent to which obesity contributes to PCOS manifestations is not very clear. This study aimed to disentangle the relative contrib…

BACKGROUND: Insulin resistance(IR) is a key mechanism underlying both obesity and metabolic syndrome, with significant implications for the onset and progression of female infertility. This study systematically examines the associations bet…

BACKGROUND: The development of assisted reproductive technology (ART) has revolutionized infertility treatment; however, its success largely depends on effective controlled ovarian stimulation (COS) and the timing of oocyte retrieval. This …

BACKGROUND: Non-invasive selection of human embryos for in vitro fertilization purposes is still a major challenge to pursue. Therefore, this study aims to identify non-invasive morphometric and secretomic parameters that reliably select th…

INTRODUCTION: Advanced endometriosis (stage III-IV, per the revised American Society for Reproductive Medicine (rARSM) classification of endometriosis) is associated with a range of pregnancy-related complications. Despite growing evidence,…

RESEARCH QUESTION: Does preimplantation genetic testing for aneuploidy (PGT-A) on cryopreserved unbiopsied blastocysts improve pregnancy outcomes for women with previous IVF-related pregnancy loss? METHODS: This retrospective observational…

BACKGROUND: The true prevalence and clinical significance of congenital uterine malformations (CUM), particularly the dysmorphic uterus, in infertile populations remain a matter of debate, largely due to historical limitations in diagnostic…

BACKGROUND: The PPOS (Progestin Primed Ovarian Stimulation) protocol has been evaluated and has proved its effectiveness in preventing the LH (luteinizing hormone) surge. This protocol is often used for cryopreservation for social reasons b…

BACKGROUND: One in six people experience infertility, often leading couples to seek Assisted Reproductive Technology (ART), which can be emotionally taxing. Anxiety and depression are common among individuals undergoing ART, highlighting th…

BACKGROUND: The quality of in vitro matured (IVM) oocytes remains inferior to that of in vivo matured oocytes, likely due to DNA damage induced by the in vitro environment. Although rapamycin has been shown to improve the developmental comp…

BACKGROUND: The posttranslational histone modification H3K9me3 is crucial for constitutive heterochromatin (cHC) and supports genome stability and gene regulation during development. This epigenetic mark persists in human sperm post histone…

BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically recognized for its role in the regulation of toxicity mediated by environmental chemicals. Recent research points to AhR's critical part…

OBJECTIVE: The relationship between sedentary behavior and infertility remains ambiguous and contentious. This study seeks to elucidate this association by analyzing data from the 2013-2018 National Health and Nutrition Examination Survey (…