Reproductive biology and endocrinology : RB&E

BACKGROUND: Previous studies have shown that due to the presence of endometrium progesterone resistance in patients with endometriosis, it is considered that higher levels of progesterone may be required to achieve live birth during program…

BACKGROUND: A prospective, observational study to identify relationships between body temperature and levels of peripheral P4 blood progesterone, and examine if these differ according to body temperature cycle pattern. METHODS: 62 data poi…

BACKGROUND: Follitropin delta (hrFSH) is the first recombinant follicle-stimulating hormone produced in a human cell line and more closely resembles native human FSH than follitropin alfa/beta (rFSH). Its efficacy and safety have been demon…

BACKGROUND: Oocyte vitrification, a widely utilized assisted reproductive technology for fertility preservation, can address emergencies arising from the unavailability of sperm from the male partner on the day of oocyte retrieval. However,…

The polycystic ovary syndrome (PCOS) is a multifaced disease of the reproductive age associated with several comorbidities including infertility. Very few documents regarding the management of the infertility in women with PCOS, including g…

BACKGROUND: While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an at…

Endometriosis is one of the most common gynecological diseases in women and is still one of the most understudied diseases, affecting the daily lives of patients. Although the exact cause of this condition remains unclear, autophagy has bee…

BACKGROUNDS: The study was designed to analyze early pregnancy loss rates in first-time fresh embryo transfer cycles in low prognosis patients according to the POSEIDON criteria. METHODS: This was a retrospective cohort study, including pa…

BACKGROUND: More than 500 patients have received cryopreserved ovarian tissue transplantation (OTT) worldwide, resulting in over 200 live births. Although guidelines recognize OTT as an effective fertility preservation method, there is no c…

BACKGROUND: Hysteroscopic septum resection has been a widespread technique throughout the world in women with a septate uterus. The effectiveness of hysteroscopic septum resection before IVF was equivocal. This study aimed to investigate wh…

BACKGROUND: Infertility represents a prevalent condition affecting the reproductive system. It has a global incidence of approximately 17.5%. Nutritional supplements are increasingly used as complementary therapy for female infertility, tho…

BACKGROUND: Endometriosis, a chronic inflammatory disorder, is a leading cause of pelvic pain and reduced quality of life in women, with oxidative stress implicated in its pathogenesis. While antioxidant supplementation has been proposed as…

BACKGROUND: Pelvic congestion syndrome(PCS) is a complex condition, with ongoing controversies regarding its diagnosis, treatment, and long-term effects, especially concerning reproductive health. Endovenous embolization performed for PCS m…

OBJECTIVE: To investigate the association between serum estradiol (E2) levels on the day of embryo transfer and clinical pregnancy outcomes in hormonally prepared frozen–thawed embryo transfer (HRT-FET) cycles with optimal progesterone (P4)…

A successful pregnancy requires that the embryo and the endometrium undergo regulated alterations during the preimplantation phase, which can have positive effects on each other due to these adaptations. The focus of this review is to study…

BACKGROUND: Premature ovarian insufficiency (POI), affecting approximately 1% of women under 40, is associated with impaired fertility. Occult POI (oPOI), an initiating form, is more challenging to detect but still allows potential success …

BACKGROUND: In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA methylation (DNAm) patt…

RESEARCH QUESTION: While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality…

The extracellular matrix is a complex network of macromolecules that support the growth and homeostatic development of organisms. By conveying multiple signaling cascades, it impacts on several biological processes and influences the behavi…

PURPOSE: We aimed to assess the impact of the timing of ovarian stimulation initiation on the number of oocytes retrieved in a progestin-primed ovarian stimulation (PPOS) protocol for oocyte donors. METHODS: A total of 110 oocyte donors wer…

BACKGROUND: endometriosis as a common gynecologic finding significantly affects the quality of life of many women. An accurate understanding of the epidemiological characteristics of endometriosis is essential for disease control and preven…

OBJECTIVE: The objective of this meta-analysis is to provide a comprehensive and up-to-date assessment of the prevalence of endometriosis and adenomyosis, addressing the limitations of existing research data and evaluating the quality of th…

BACKGROUND: Programmed protocols are most commonly chosen as endometrial preparation for women with polycystic ovarian syndrome (PCOS) undergoing frozen-thawed embryo transfer (FET) cycles. However, the efficacy of gonadotropin-releasing ho…

OBJECTIVE: To study the correlation between anti-Müllerian hormone levels and pregnancy outcomes after in vitro fertilization/intracytoplasmic sperm injection in women with polycystic ovary syndrome, which remains controversial. METHODS: T…

BACKGROUND: Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure t…