The Journal of molecular diagnostics : JMD

J Mol Diagn · ISSN (e) 1943-7811 · 4 papers in corpus
2024
Improving Specificity for Ovarian Cancer Screening Using a Novel Extracellular Vesicle-Based Blood Test: Performance in a Training and Verification Cohort.
doi:10.1016/j.jmoldx.2024.09.001 ·PMID:39326669

The low incidence of ovarian cancer (OC) dictates that any screening strategy needs to be both highly sensitive and highly specific. This study explored the utility of detecting multiple colocalized proteins or glycosylation epitopes on sin…

other 2024
The Application of Knowledge Engineering via the Use of a Biomimetic Digital Twin Ecosystem, Phenotype-Driven Variant Analysis, and Exome Sequencing to Understand the Molecular Mechanisms of Disease
doi:10.1016/j.jmoldx.2024.03.004 ·PMID:38556123

Applied artificial intelligence, particularly large language models, in biomedical research is accelerating, but effective discovery and validation requires a toolset without limitations or bias. On January 30, 2023, the National Academies …

article 2015
Panels of Cytokines and Other Secretory Proteins as Potential Biomarkers of Ovarian Endometriosis
doi:10.1016/j.jmoldx.2015.01.006 ·PMID:25797583

Endometriosis is a gynecologic disease that is characterized by nonspecific symptoms and invasive diagnostics. To date, there is no adequate noninvasive method for the diagnosis of endometriosis. Although more than 100 potential biomarkers …

2013
Comparison of clinical targeted next-generation sequence data from formalin-fixed and fresh-frozen tissue specimens.
doi:10.1016/j.jmoldx.2013.05.004 ·PMID:23810758

Next-generation sequencing (NGS) has emerged as a powerful technique for the detection of genetic variants in the clinical laboratory. NGS can be performed using DNA from FFPE tissue, but it is unknown whether such specimens are truly equiv…