Obstetrics & Gynecology Science

OBJECTIVE: Endometriosis (EM) is a chronic gynecological condition of unclear etiology, with evidence suggesting a link between metabolite levels and EM risk. A two-sample Mendelian randomization (MR) approach was used to explore the associ…

OBJECTIVE: To determine whether hysterectomy for benign diseases is associated with the risk of dementia in middle-aged women. METHODS: We conducted a retrospective cohort study using data from the Korean National Health Insurance Service …

OBJECTIVE: To evaluate whether endometriosis (EMS) adversely affects the embryological and clinical outcomes of assisted reproductive technology (ART) in poor ovarian responders (PORs) with repeated implantation failure undergoing spindle v…

OBJECTIVE: Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is associated with reduced postoperative pain and faster recovery compared with conventional laparoscopy. However, its adoption is limited by challenging triangulat…

OBJECTIVE: Endometriosis remains an underdiagnosed gynecological condition due to the lack of validated non-invasive biomarkers. This study aimed to evaluate the diagnostic value of plasma interleukin-6 (IL-6), serum cancer antigen 125 (CA1…

Over the past 20 years, as the number of women of reproductive age in Korea diagnosed with uterine leiomyoma and adenomyosis prior to pregnancy has increased, fertility-preserving uterine surgeries such as myomectomy and adenomyomectomy hav…

Adenomyosis, a prevalent yet frequently underdiagnosed uterine disorder, poses significant challenges for women of reproductive age, especially those seeking fertility. Although hysterectomy remains the definitive treatment, fertility-spari…

OBJECTIVE: Endometriosis affects 5-10% of reproductive-aged women and is characterized by chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. Standard hormonal therapies, such as dienogest, effectively manage symptoms, but are …

Vaginal hysterectomy remains the least invasive approach for benign gynecologic diseases, but has steadily declined due to limited surgical exposure during residency. Transvaginal natural orifice transluminal endoscopic surgery (vNOTES) has…

OBJECTIVE: Dysregulation of leukocyte cell number as a cause of heavy menstrual bleeding (HMB) has not been investigated much. The present study compares the changes in the number of uterine natural killer (uNK) cells, T cells, and macropha…

Endometriosis, a prevalent but debilitating condition affecting women, poses significant challenges in diagnosis and management. The current 2024 guideline, developed by the Korean Society of Endometriosis (KSE), builds upon the 2018 KSE gu…

Placenta accreta spectrum (PAS) is defined by abnormal placental adherence or invasion into the myometrium or adjacent organs and is a leading cause of massive obstetric hemorrhage. Its global incidence is increasing due to rising cesarean …

This systematic review and meta-analysis of randomized controlled trials (RCTs) assessed the effect of L-carnitine (LC) supplementation on the fertility outcomes of patients with polycystic ovary syndrome (PCOS). Online databases (Scopus, W…

OBJECTIVE: The objective of our study was to characterize the sperm parameters of men consulting for infertility in our fertility center. METHODS: The study included 3,025 patients investigated from September 2021 to July 2023. Demographic…

This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane L…

OBJECTIVE: Natural orifice transluminal endoscopic surgery (NOTES) for hysterectomy conventionally requires CO2 pneumoperitoneum via a transvaginal port, presenting challenges such as gas leakage and increased procedural complexity. We intr…

OBJECTIVE: To compare obstetric and perinatal outcomes between assisted reproductive technology (ART)-conceived and spontaneously conceived twin pregnancies using a nationwide Korean cohort. METHODS: This retrospective cohort study used Ko…

Gynecological cancer is a life-threatening malignancy among women. Traditional therapies, including chemotherapy, often face challenges in terms of chemotherapeutic drug solubility and resistance, specificity, tumor site targeting, and toxi…

OBJECTIVE: Endometriosis is the presence of endometrial tissue outside of the uterine cavity. Certain markers have been used to evaluate the severity of endometriosis. This study aimed to explore the correlation between red blood cell (RBC)…

OBJECTIVE: We aimed to introduce the clinical experience with a new surgical technique, single-port access laparoscopic fundusectomy, and a more efficient uterus-sparing surgical method for treating multiple fibroids in patients without a p…

OBJECTIVE: Geriatric patients requiring gynecological surgery is increasing worldwide. However, older patients are at higher risk of postoperative morbidity and mortality, particularly cardiopulmonary complications. Laparoscopic surgery is …

OBJECTIVE: The study aimed to compare the effectiveness and side effects of 600 μg of oral Misoprostol with 10 international units (IU) intramuscular oxytocin in managing the third stage of labor. METHODS: This open-label, randomized contr…

OBJECTIVE: Uterine leiomyoma is a common gynecological condition that negatively affects women's quality of life. Vitamin D plays an important role in tumor development and progression. However, clinical studies comparing serum vitamin D le…

OBJECTIVE: Fetal uterine survival depends on maintaining an immune balance between the mother and fetus. This study aimed to investigate the correlation of blood peripheral natural killer (NK) cells and interferon-gamma (IFN-γ) with recurre…

Significant progress has been made in the molecular diagnosis of cancer. It provides personalized medicine, including cancer diagnosis, prognosis, targeted therapy, and risk detection. These advances allow physicians to identify patients at…