Scientific reports

Infertility has emerged as a significant global health concern. Assisted reproductive technology (ART) assists numerous infertile couples in conceiving, yet some experience repeated, unsuccessful cycles. This study aims to identify the pivo…

Studies have suggested transferring Day 6 (D6) vitrified blastocyst in a frozen embryo transfer (FET) cycle. This study investigates whether D6 blastocysts should be transferred on the 5th or 6th day of progesterone administration during a …

Neutrophils are key immune components in rheumatoid arthritis (RA), but the role of ALKBH5 in neutrophil function and RA progression remains unclear. METTL3, METTL14, WTAP, ALKBH5, FTO, YTHDF2, autophagy related gene were investigated by RT…

Perfluorooctane sulfonate (PFOS) is a widely used chemical in industrial production. It can be introduced into the environment through multiple pathways and exhibits resistance to degradation. Recent research has demonstrated a significant …

Uterine fibroids are common among women of reproductive age and often recur after treatment. Accurate recurrence prediction is essential for guiding clinical decisions, yet existing models remain inadequate. This study aimed to develop a no…

Ectopic pregnancy (EP) is a common yet fatal complication of in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI). We aim to establish and validate a nomogram in patients undergoing double fresh cleava…

Hypertensive disorders of pregnancy (HDP) remain a leading cause of maternal and perinatal morbidity worldwide, and current screening strategies have limited predictive value in low-risk populations especially for late-onset HDP. This study…

Diagnosis of endometriosis faces significant challenges including diagnostic delay and reliance on invasive procedures. Deep endometriosis (DE) poses additional difficulties in non-invasive diagnosis due to its subtle and complex imaging fe…

Postoperative adhesions frequently occur following abdominal surgical interventions, leading to serious morbidities and requiring new therapeutic strategies. The development of new therapeutic agents to reduce postoperative adhesions needs …

Despite advances in cancer treatments, epithelial ovarian cancer (EOC) remains the leading cause of death among gynecologic cancers. EOC is stratified into five main histopathological subtypes: high-grade serous carcinoma (HGSC), low-grade …

The healthy progression and termination of pregnancy depend critically upon embryo development, acquisition of uterine receptivity, implantation, and decidualization during the peri-implantation period. Sumoylation is a post-translational m…

This retrospective cohort study evaluated whether gonadotropin-releasing hormone agonists (GnRHa) used for luteal support during antagonist cycles improved pregnancy outcomes in patients undergoing fresh embryo transfer. We examined 3,115 p…

Assisted hatching (AH) is a reproductive technique that artificially thins or breaches the zona pellucida to facilitate hatching. Despite its widespread use, there is insufficient evidence to conclude that AH improves pregnancy outcomes, pa…

China has a high prevalence of the hepatitis B virus (HBV), and many patients seeking assisted reproductive technologies are infected. This study investigated the relationship between male HBV infection and intrauterine insemination (IUI) o…

This study aimed to evaluate the association between hysterectomy and the risk of thyroid cancer and benign thyroid disorders in South Korean women. A retrospective cohort study was conducted using Korean National Insurance data from 2002 t…

Testosterone modulated by exercise plays a pivotal role in maintaining the overall health of both males and females. Therefore, this study aimed to determine the effects of an integrated exercise approach on total testosterone levels during…

Anesthetic techniques can significantly influence postoperative outcomes by modulating inflammatory cytokine release and oxidative stress (OS). This study aimed to compare serum levels of OS biomarkers and inflammatory cytokines in patients…

To determine the efficacy and safety of selective laser trabeculoplasty (SLT) in patients with uveitic glaucoma, we retrospectively evaluated 17 eyes from 13 consecutive uveitic glaucoma cases who were treated with SLT due to inadequate int…

Subfertility affects about 10-15% of Malaysians, characterized by difficulty conceiving after 12 months of unprotected intercourse. Emerging research suggests that vitamin D deficiency, influenced by dietary intake and sleep patterns, may c…

We assessed the effects of endometrial injection of embryo culture supernatants on assisted reproductive technology (ART) outcomes in frozen-thawed embryo transfer (FET) cycles. Hormone replacement therapy cycles with blastocyst transfer on…

It has been debated whether endometriosis (EMS) adversely affects oocyte quality, potentially leading to a higher incidence of genetically unbalanced embryos or other egg factors that affect the developmental potential. In this study, we ex…

An ion-sensitive field-effect transistor (ISFET) is widely used in environmental and biomedical applications due to its rapid response, miniaturization, and cost-effectiveness. In this study, a numerical model of an Al₂O₃-gated ISFET was de…

This study aims to evaluate whether laparoscopic surgery enhances health-related quality of life (HRQoL) in endometriosis patients, utilizing the Endometriosis Health Profile-30 (EHP-30) questionnaire. The study also explores the correlatio…

This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. This study utilized genome-wide association study (GWAS) summary s…

Even though non-invasive prediction of endometriosis may seem technically feasible using sophisticated machine learning algorithms, a standard clinical use case for non-surgical diagnosis of endometriosis has not yet been established. In th…