Brain and behavior

ObjectivesThe objectives were to evaluate the prevalence of comorbidities at the time of multiple sclerosis (MS) diagnosis in a Finnish cross-sectional cohort and to analyze whether comorbidities at diagnosis associate with clinical charact…

BACKGROUND: The C-reactive protein-triglyceride glucose index (CTI) has been established as a novel biomarker reflecting insulin resistance and systemic inflammation. However, its association with unfavorable outcomes in acute ischemic stro…

INTRODUCTION: Inflammation has been implicated in both reproduction and sleep; however, the relationships remain unclear, and conclusive evidence for genetic associations is lacking. METHODS: This study utilized the 2013-2020 National Heal…

INTRODUCTION: Persistent musculoskeletal pain is associated with altered functional and effective connectivity (EC) between cortical regions involved in pain processing. Especially, disruptions in the infraslow fluctuation (ISF) frequency b…

BACKGROUND: Cerebral venous thrombosis (CVT) is a stroke type that primarily affects young individuals, with various risk factors and complex mechanisms. It accounts for 0.5% to 3% of all stroke cases and can significantly impact daily acti…

OBJECTIVE: To identify potential druggable targets for Alzheimer's disease (AD) by analyzing circulating inflammatory proteins using Mendelian randomization (MR). METHODS: Two-sample MR analysis was employed to investigate the causal relat…

INTRODUCTION: Premenstrual syndrome (PMS) affects nearly half of women worldwide and is associated with sleep disturbances, though the specific relationship between PMS and nightmares remains underexplored. Clinical observations suggest a p…

AIM: In the aftermath of natural disasters, understanding the intricate links between mental health and physiological responses, such as menstrual cycle patterns, becomes crucial. This study explores the relationship between post-traumatic …

INTRODUCTION: The primary objective of this paper is to (1) provide a summary of human studies that have used brain derived neurotrophic factor (BDNF) as a biomarker, (2) review animal studies that help to elucidate the mechanistic involvem…

BACKGROUND: This study explores sex-specific differences in pain localization using pain drawings in female patients with endometriosis. Traditional human body outlines (HBOs) used for pain drawings are often viewed as male, making accurate…

INTRODUCTION: Autoantibodies to the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor and N-methyl-d-aspartate (NMDA) receptor are known to be the causes of autoimmune encephalitis particularly limbic encephalitis. Th…