Endocrinology

The mechanism of glucocorticoid antagonism of estradiol-stimulated uterotrophic responses was studied. Dexamethasone was administered sc at a dosage of 1000 μg 20–25 min before an injection of 1 μg estradiol. Uterine weights were measured a…

The effects of danazol on steroidogenesis in vitro in the rat testis were examined by studying: 1) androgen synthesis in rat Leydig cells cultured with danazol, 2) danazol binding to rat testis microsomal cytochrome P-450, and 3) enzyme kin…

Serum progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations were estimated in intact and hysterectomized pseudopregnant rats. Progesterone concentrations increased significantly from day 2 of pseudopre…

In (RXU)F1 hybrid rats delayed pseudopregnancy was induced in three different ways: 1) by removal of all recent corporl lutea on day 2 of pseudopregnancy, 2) by removal of the in situ ovaries from ovarian graft-bearing animals on day 0 of p…

Pseudopregnancy was induced in rabbits by a single iv injection of 100 IU of human chorionic gonadotrophin (hCG). Uterine norepinephrine, located exclusively in adrenergic nerves, was markedly reduced (fluorometric determinations) during th…

Sexually mature, intact, female rats were selected at various stages of the estrous cycle as determined by the vaginal smear method. Ovariectomized rats were treated with estrogen, orprogesterone or estrogen plus progesterone. Uterine tissu…

Journal Article The Effect of Hypophysectomy on Day 12 of Pregnancy on the Serum Progesterone Level and Time of Parturition in the Rat Get access G. PEPE, G. PEPE *Department of Reproductive Biology, Case Western Reserve University School o…

The effects of ergocornine, estradiol benzoate (EB) or both on anterior pituitary (AP) and serum prolactin concentrations were studied in ovariectomized or hypophysectomized rats with a pituitary transplant, and directly on the AP in vitro.…

Hypophysial homografts equivalent to ½ or ½ of a pituitary gland were transplanted to the kidney of female rats 7 days after hypophysectomy. When examined 7 days after transplantation, the persistent nonfunctional corpora lutea (CL) had und…

The mode of action of ergocornine was investigated by means of 2 different experimental procedures. A first group of animals was composed of hypophysectomized female rats bearing a pituitary under the kidney capsule, and daily injected with…

Journal Article On the Mechanism of Ovarian Hypertrophy Following Hemicastration in Rats Get access RICHARD A. EDGREN, RICHARD A. EDGREN 1Research Division, Wyeth Laboratories, Inc. Philadelphia, Pennsylvania; Department of Physiology, Emor…

In dbaxce and reciprocally crossed hybrid mice hyperplasia of the uterus occurs spontaneously in both intact virgin and neonatally ovariectomized females at 6 to 8 months of age and persists throughout life (Christy, Dickie, Atkinson and Wo…

The administration of massive doses of estrogens to monkeys has been demonstrated to produce squamous metaplasia of the endocervical mucosa and cystic hyperplasia of the endometrium. The present report is made to direct attention to the fac…

The production of an inhibition of the estrous cycle in the rodent has been reported repeatedly with the use of various hormones as well as with other agents. The mechanism is obviously complicated, for anestrus may be produced through the …