FAILURE OF MASSIVE DOSES OF ESTROGEN TO PROMOTE GROWTH OF ENDOMETRIAL COILED ARTERIOLES

The administration of massive doses of estrogens to monkeys has been demonstrated to produce squamous metaplasia of the endocervical mucosa and cystic hyperplasia of the endometrium. The present report is made to direct attention to the fact that estrogenic stimulation of this magnitude can induce excellent proliferative activity of endometrial glands and stroma without proliferation of endometrial coiled arterioles. In addition, further observations in reference to cervical epiderniidization and endometrial hyperplasia have been made. observations Six rhesus monkeys (Macaca mulatta) were given 25,000 I.U. of Amniotin2 a day from February 11 through March 8 with the exception of No. 182 which was treated through March 4 only. They were all mature female castrates, resident in the colony of the Department of Embryology for several years. They had been employed during the previous six months in a series of estrogen and estrogen-progesterone withdrawal studies, in the course of which they demonstrated the expected patterns of menstruation-like bleeding.