Nan fang yi ke da xue xue bao = Journal of Southern Medical University

OBJECTIVE: To establish a diagnostic model of endometriosis by analyzing serum peptidome patterns in patients with endometriosis using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). METHODS: Ser…

OBJECTIVE: To explore the roles of matrix metalloproteinase-1(MMP-1) and tissue inhibitor of metalloproteinase-1(TIMP-1) in the pathogenesis of endometriosis and the effects of estrogen and progestin on their expression. METHODS: Immunohist…

OBJECTIVE: To construct a lentiviral expression vector for short hairpin RNA (shRNA) of human survivin gene, and assess its gene silencing effect in human ectopic endometrial cells. METHODS: Human survivin gene shRNA sequence was designed …

OBJECTIVE: To analyze the ultrastructural characteristics of ectopic endometrium in endometriosis. METHODS: Ectopic endometria collected from patients with adenomyosis and ovarian endometriosis were examined under transmission electron micr…

OBJECTIVE: To detect the expression of fragile histidine triad in endometriosis and investigate the pathogenesis of endometriosis. METHODS: immunohistochemistry was used to examine the expression of Fhit in the eutopic and ectopic endometr…

OBJECTIVE: To investigate the effect of small interference RNA (siRNA) targeting nuclear factor-kappaB (NF-kappaB) on endometriosis. METHOD: The eutopic endometrium of women with endometriosis were transplanted into the nonvascular region o…

OBJECTIVE: To investigate the effect of laparoscopic surgery on the immune function of patients with endometriosis. METHOD: Blood samples were obtained from 36 patients undergoing laparoscopy for endometriosis before and 1 day and 3 days af…

OBJECTIVE: To investigate the expression of vascular endothelial growth factor (VEGF) in eutopic and ectopic endometrium of in nude mice models of endometriosis and understand the role of VEGF in the development of endometriosis. METHODS: N…

OBJECTIVE: To detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis. METHODS: Immunohistochemistry was performed to examine the…

OBJECTIVE: To study the polymorphism of +252 site in intron 1 of tumor necrosis factor (TNF)-beta gene in relation to genetic susceptibility of endometriosis. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-…

OBJECTIVE: To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis. METHODS: Seventy patients with adenomyosis diagnosed according to clinical symptoms, magnetic resonan…