Othman EE

No ORCID on file · 4 papers in corpus · active 2007-2009

Study types

  • review 2
  • article 1
  • other 1

Condition tags

  • endometriosis 4
review 2009
Gene therapy of benign gynecological diseases
Advanced drug delivery reviews ·doi:10.1016/j.addr.2009.04.023

Gene therapy is the introduction of genetic material into patient's cells to achieve therapeutic benefit. Advances in molecular biology techniques and better understanding of disease pathogenesis have validated the use of a variety of genes…

review 2009
Reassessing the evidence for the link between dioxin and endometriosis: from molecular biology to clinical epidemiology
Molecular human reproduction ·doi:10.1093/molehr/gap075

A 1993 study reporting the link between exposure to dioxin and the risk of developing endometriosis in rhesus monkeys prompted many investigators to look suspiciously at dioxin. Since 1993, many in vitro, animal and epidemiological studies …

article 2008
Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells
American journal of obstetrics and gynecology ·doi:10.1016/j.ajog.2008.01.059

ObjectiveThe purpose of this study was to screen a panel of targeted adenoviruses as vectors for endometriosis gene therapy.Study designEndometriotic cells were obtained from subjects with ovarian endometriomas. Liver tissues were taken fro…

other 2007
Toward gene therapy of endometriosis: adenovirus-mediated delivery of dominant negative estrogen receptor genes inhibits cell proliferation, reduces cytokine production, and induces apoptosis of endometriotic cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2006.11.046

OBJECTIVE: To use dominant negative mutants of estrogen receptor genes delivered to endometriosis cells via an adenovirus vector (Ad-DN-ER) to abrogate estrogen action on these cells. DESIGN: Experimental in vitro study. SETTING: Universi…