Ying Cheong

INTRODUCTION: Chronic pelvic pain (CPP) affects more than 1 million UK women with associated healthcare costs of £158 million annually. Current evidence supporting interventions when no underlying pathology is identified is very limited and…

INTRODUCTION: Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracyt…

BACKGROUND: Endometriosis affects about 4% of women in the reproductive age and is associated with subfertility. The aim of the present study is to examine the integrated quantitative proteomic profile of eutopic endometrium and serum from …

Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised,…

Objective: Postoperative adhesions occur in 80% of cases of gynecological surgery. Therefore evidence-based recommendations have been made to improve surgeons´ knowledge of postoperative adhesion formation and preventive strategies. The obj…

Endometriosis is an enigmatic disorder that is fraught with management controversies and very often, there exist deep divides in management strategies among the generalist, the specialist who favours surgery, the specialist who favours medi…

Housekeeping genes (HKG) are presumed to be constitutively expressed throughout tissue types but recent studies have shown they vary with pathophysiology. Often, validation of appropriate HKG is not made. There is no consensus on which HKGs…

IntroductionPeriadnexal adhesions are known to contribute to subfertility. The restoration of the tubo-ovarian anatomy is one the key principles in reproductive surgery, and this involves adhesiolysis. However, adhesion formation/reformatio…

There is molecular evidence that endometriosis has a negative impact on the ovaries, although the exact pathophysiology concerning endometriosis-associated subfertility is not known. The negative impact on the tubo-ovarian unit can be direc…

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known if DNA damage is the primary trigger for arrest, or if…

Study questionDo the amino acid levels of human uterine fluid vary with age, BMI, phase of menstrual cycle, benign pathology or diet?Summary answerThe levels of 18 amino acids in human uterine fluid were shown to be affected only by materna…

Human Development and Health Unit, University of Southampton, United Kingdom and Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Human Development and Health Unit, University of So…

This review has been replaced by published review 'Non‐surgical interventions for the management of chronic pelvic pain'. It will also be replaced by current protocol 'Surgical interventions for the management of chronic pelvic pain in wome…

BACKGROUND: Endometriosis is a disease known to be detrimental to fertility. Women with endometriosis, and the presence of endometrioma, may require artificial reproductive techniques (ART) to achieve a pregnancy. The specific impact of end…

OBJECTIVE: To investigate the association of endometriosis on assisted reproductive technology (ART) outcomes and to review if surgical treatment of endometriosis before ART affects the outcomes. DATA SOURCES: We searched studies published …

BACKGROUND: Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors. The management of chronic pelvic pain is challenging, as despite interventions …

BACKGROUND: Pelvic adhesions are found in up to 50% of women with CPP during investigative surgeries and adhesiolysis is often performed as part of their management although the causal or casual association of adhesions, and the clinical be…

Endometriosis is a disease whereby endometrial-like tissue exists outside the uterus. The exact prevalence of endometriosis is unknown, although it is estimated that up to 10% of women in the general population and up to 50% of subfertile w…

The management of tubal disease depends on the initial pathological process and the severity of damage. In vitro fertilisation (IVF) remains the main treatment strategy for women with severely damaged fallopian tubes. The main causes of tub…

STUDY QUESTION: How do the expression patterns of neuronal markers differ in the endometrium of women with and without endometriosis? SUMMARY ANSWER: The neuronal markers, PGP9.5, NGFp75 and VR1, are expressed in the endometrium at levels …

Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view o…