Katharina Held

No ORCID on file · 7 papers in corpus · active 2015-2026

Study types

  • other 6
  • article 1

Condition tags

  • infertility 1
other 2026
A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3
Communications chemistry ·doi:10.1038/s42004-026-01889-9

Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception. Moreover, gain-of-function variants in TRPM3 underlie a spectrum of ne…

other 2023
Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders
eLife ·doi:10.7554/eLife.81032

TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in TRPM3 were identified in individuals with developmental and epil…

other 2023
Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-023-01085-7

BACKGROUND: Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo development and endometrial receptivity must be synchronized and an adeq…

other 2022
Loratadine, an antihistaminic drug, suppresses the proliferation of endometrial stromal cells by inhibition of TRPV2
European journal of pharmacology ·doi:10.1016/j.ejphar.2022.175086

The transient receptor potential (TRP) channel TRPV2 is widely expressed in a variety of different cell types and tissues. However, elucidating the exact biological functions of TRPV2 is significantly hampered by the lack of selective pharm…

other 2022
Urine-Derived Kidney Progenitor Cells in Cystinosis
Cells ·doi:10.3390/cells11071245

Nephropathic cystinosis is an inherited lysosomal storage disorder caused by pathogenic variants in the cystinosin (CTNS) gene and is characterized by the excessive shedding of proximal tubular epithelial cells (PTECs) and podocytes into ur…

other 2019
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids
Scientific reports ·doi:10.1038/s41598-018-38376-8

Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is inadequate due to limited acce…

article 2015
Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle
·doi:10.1093/humrep/dev068

STUDY QUESTION: Are members of the transient receptor potential (TRP) channel superfamily functionally expressed in the human endometrial stroma? SUMMARY ANSWER: The Ca(2+)-permeable ion channels TRPV2, TRPV4, TRPC6 and TRPM7 are functional…