Liu X

ObjectiveTo explore the factors associated with elevated serum progesterone (P) levels on the day of hCG administration in patients undergoing controlled ovarian stimulation using a gonadotropin-releasing hormone antagonist (GnRH-A) protoco…

Adenomyosis and endometriosis are two sister diseases that cause menstrual pain and other symptoms. We have previously reported that patients with these conditions have a less active 'calm-and-rest' system and a more active 'stress-and-aler…

Apoptotic cells release a highly heterogeneous population of extracellular vesicles, which can be categorized into apoptotic bodies, apoptotic microvesicles, and apoptotic exosomes. These apoptotic vesicles (apoVs) not only inherit material…

ObjectiveTo evaluate the efficacy and safety of an "oral simulated tube feeding method" compared to nasogastric feeding in patients with moderately severe acute pancreatitis (MSAP).MethodsIn this randomized controlled non-inferiority trial,…

Objective This study aimed to develop a predictive model for ovarian endometrioma (OE) recurrence in patients with congenital obstructive Müllerian anomalies (OMAs) undergoing surgical intervention. Methods This retrospective cohort study i…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder associated with impaired fertility and reduced quality of life. This study investigated abnormal spindle-like microcephaly-associated protein (ASPM), identified as a hub gen…

Ovarian response to controlled ovarian stimulation (COS) is a core determinant of assisted reproductive technology (ART) success, with marked interindividual variability. Accurate and individualized prediction is essential to optimize treat…

ObjectiveTo investigate the association between the ovarian sensitivity index (OSI) and ovarian responsiveness, embryo quality, and pregnancy outcomes in women of advanced reproductive age (≥35 years) undergoing IVF-ET.MethodsThis retrospec…

BackgroundChronic rhinosinusitis (CRS) is a heterogeneous inflammatory sinonasal disease with variable radiologic and symptom burden. Dietary antioxidant capacity and insulin resistance may be related to CRS burden, but their interrelations…

BackgroundMitochondrial dysfunction contributes to poor embryo quality and recurrent assisted reproductive technology (ART) failure. Mitochondrial transplantation (MIT), which involves supplementing oocytes with exogenous mitochondria, has …

BackgroundOvarian clear cell carcinoma (OCCC) is a distinct subtype of epithelial ovarian cancer with characteristic biological behavior and clinical features. Accurate preoperative staging is essential for guiding optimal management; howev…

STUDY QUESTION: What is the current landscape of randomized controlled trials (RCTs) evaluating stem cell-based therapies for women's reproductive diseases, and how effectively has preclinical research informed their clinical translation? …

Primary aldosteronism (PA) is associated with a substantially higher cardiovascular risk than essential hypertension, a disparity that cannot be fully explained by blood pressure elevation alone. Clinical studies consistently demonstrate th…

BACKGROUND: Emerging evidence implicates the gut microbiota in the pathogenesis of adenomyosis (AM); however, whether this association is causal and through which mechanisms it operates remain largely unknown. METHODS: To interrogate poten…

Ovarian cancer remains a significant global health burden, with high-grade serous ovarian cancer (HGSOC) representing the most lethal subtype. Bulk RNA-seq analysis revealed KLK5 (Kallikrein-5, a serine protease) upregulation in ovarian can…

Mitochondrial dysfunction has been demonstrated with a role in pathologically driving various obstetric and gynecological (OB/GYN) diseases, but molecular mediators associating mitochondrial dysfunction with discrete pathologies have not be…

BACKGROUND: Ultrasound-based deep learning (DL) models for the precise diagnosis of endometrial cancer are insufficient. Our aim is to develop and validate an automatic multi-modal ultrasound DL prediction model for the accurate identificat…

BACKGROUND: Regional and hierarchical disparities in gynecological care may compromise equity and quality in China. Assessing structural resources, clinical processes, and outcomes is critical to guide system improvement. METHODS: We conduc…

Endometriosis is a prevalent gynecological disorder associated with chronic low-grade inflammation, yet diagnosis is often delayed because symptoms are non-specific and definitive confirmation typically relies on invasive procedures. Compos…

IntroductionSubinvolution of the postpartum uterus is a common puerperal complication. While Chinese herbal hot compress (CHHC) therapy has been widely applied to promote postpartum uterine involution, its underlying mechanisms remain uncle…

IntroductionAcupuncture has been explored as a potential intervention for POR; however, high-quality evidence is limited. This multicenter randomized trial evaluated the effect of acupuncture on the number of oocytes retrieved following con…

IntroductionDiminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Acupuncture maybe effective for DOR, but current e…

BackgroundGonadotropin releasing hormone analogs (GnRHa) are recommended for both central precocious puberty (CPP) and early and fast puberty, but their benefit on final adult height in later onset cases remains controversial. Boennuokang® …