Bruno Piras

INTRODUCTION: Endometriosis is a chronic disease characterized by endometriotic cells implanted outside the uterus triggering a chronic inflammatory state. Estradiol stimulates the endometriotic implants, which overexpress estrogen receptor…

Uterine fibroids (UFs) are the most common gynaecological benign disease. Even though often asymptomatic, UFs can worsen women's health and their quality of life, causing heavy bleeding and anaemia, pelvic discomfort and reduced fertility. …

This observational study was conducted in premenopausal women who presented themselves at the Obstetrics and Gynecology Department of the University Hospital of Cagliari (Italy), for heavy menstrual bleeding (HMB) dependent on uterine myoma…

OBJECTIVES: To evaluate the diagnostic accuracy of 2-dimensional (2D) and 3-dimensional (3D) transvaginal ultrasonography (US) in comparison with magnetic resonance imaging (MRI) for identification of deep infiltrating endometriosis. METHO…

INTRODUCTION: Suppression of sex-steroid secretion is required in a variety of gynecological conditions. This can be achieved using gonadotropin releasing hormone (GnRH) agonists that bind pituitary gonadotropin receptors and antagonize the…

Deep pelvic endometriosis is defined as subperitoneal infiltration of endometrial implants in the uterosacral ligaments, rectum, rectovaginal septum, vagina, or bladder. Although laparoscopy and biopsy remain the gold standard for diagnosis…

The diagnosis rate of deep pelvic endometriosis is increasing. Endometrial stromal sarcoma (ESS) is a rare neoplasm. Extragenital ESS is an extremely uncommon event. Very few cases of extragenital ESS have been reported to date. The diagnos…

Ultrasonography has been proposed recently for use in the diagnosis of bladder endometriosis due to the presence of hypoechogenic or isoechogenic nodules in the bladder wall and nodules with heterogeneous echostructure containing numerous a…

To evaluate 1. the prevalence of ultrasonographic diagnosis of deep endometriosis in patients with clinical suspicion and 2. to assess mean gray value (MGV) of nodules of deep endometriosis in different location also evaluating the reproduc…

To present a rare case of endometrial stromal sarcoma arising in endometriosis of the rectovaginal septum. A 57-year-old postmenopausal woman with no apparent previous history of endometriosis presented with recent onset of pelvic pain. Tra…

Deep infiltrating endometriosis can also involve the bladder and is associated with severe chronic pelvic pain and dysuria. Transvaginal ultrasonography (TVS) is considered the first-line procedure in the assessment of deep endometriosis. T…

Abstract Deep pelvic endometriosis is defined as subperitoneal infiltration of endometrial implants in the uterosacral ligaments, rectum, rectovaginal septum, vagina, or bladder. Although laparoscopy and biopsy remain the gold standard for …

OBJECTIVE: To determine the accuracy of transvaginal ultrasonography (TVUS) using a modified "tenderness-guided" approach in the diagnosis of deep endometriosis of the cul-de-sac, retrocervical region, and rectovaginal septum. DESIGN: Pros…

To determine the accuracy of transvaginal sonography in the diagnosis of deep endometriosis of the cul-de-sac, retrocervical region and rectovaginal septum using a modified and ‘tenderness-guided’ approach. In a prospective study 30 women s…

STUDY OBJECTIVE: To evaluate the clinical efficacy and patient satisfaction of long-term danazol delivered vaginally as treatment for heavy menstrual bleeding. DESIGN: Prospective study (Canadian Task Force classification II-3). SETTING: …

To demonstrate the advantages of laparoscopic management of endometriomas in comparison with laparotomy, 32 premenopausal nonpregnant women, 18–40 years of age, without acute pelvic symptoms, were prospectively submitted to surgical managem…

OBJECTIVE: To compare laparoscopy and laparotomy in the management of benign adnexal cysts, with particular attention to postoperative convalescence. METHODS: Forty premenopausal, nonpregnant women, 18-40 years of age and without acute pel…

Reproductive Medicine Unit Department of obstetrics and Ginecology University of Bologna,Italy. \nDepartment of obstetrics, Ginecology and Reproductive Science Mount Sinai School of Medicine New York, USA