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OBJECTIVE: To introduce a novel hysteroscopic suture fixation technique using a "pre-fabricated knot". This is used for levonorgestrel-releasing intrauterine system placement in adenomyosis treatment. DESIGN: Step-by-step video of "pre-fab…

BackgroundEmbryo implantation failure and early pregnancy loss remain significant challenges in assisted reproductive technology (ART). Lipid peroxidation is known to be involved in reproductive physiology. However, its role during the impl…

Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear. While nicotinamide N-methyltransferase (NNMT) is abundantly expressed in huma…

BackgroundThe aim of the retrospective cohort study was to investigate the prognostic effect of subchorionic hematomas (SCH) in the first trimester on pregnancy outcomes after euploid embryo transfer.MethodsWe retrospectively analyzed women…

BackgroundThe association of dyslipidemia with embryo development and pregnancy outcomes is largely unknown, especially in unexplained recurrent implantation failure (uRIF) patients. Here, this study aimed to explore the impact of abnormal …

ImportanceImplantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used to improve the probability of implantation and pregnancy, although the evidence for efficacy is i…

BackgroundRecurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and developme…

Increasing evidence has revealed a close relationship between non-coding RNAs and recurrent implantation failure (RIF). However, the role of circular RNAs (circRNAs) in RIF pathogenesis remains largely unknown. Microarray analyses were used…

Cervical cancer is the most common gynecological cancer in women worldwide. Human papillomavirus (HPV) is required but not sufficient for developing cervical cancer. HPV E6 and E7 proteins are able to directly interact with certain nuclear …

Background: Perineural invasion (PNI) is correlated with negative prognosis in multiple cancers, but its role in endometrial cancer (EC) is still largely unknown; thus, targeted treatment for nerve infiltration is lacking as well. Methods: …

ObjectiveThis study aimed to provide insight into the effect of time interval between loop electrosurgical excision procedure (LEEP) and subsequent hysterectomy on postoperative infectious morbidity in cervical neoplasia patients.MethodsIn …

PurposeTo evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF).MethodsEndometrial miRNA and mRNA expression profiles during the implantation window derived from wom…

Copy number variations (CNVs) have been shown to cause numerous diseases, however, their roles in human lifespan remain elusive. In this study, we investigate the association of CNVs with longevity by comparing the Han Chinese genomes of lo…