Brice Gaudillière

ORCID: 0000-0002-3475-5706 · 4 papers in corpus
2026
Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing
bioRxiv : the preprint server for biology ·doi:10.64898/2026.07.17.739227

Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. We developed CDRPipe (Computational Drug Repurpo…

other 2025
A Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Novel Therapeutics For Endometriosis Pain
bioRxiv : the preprint server for biology ·doi:10.1101/2025.05.28.656743

INTRODUCTION AND METHODS: Endometriosis has limited treatment options, prompting the search for novel therapeutics. We previously used a transcriptomics-based computational drug repositioning pipeline to analyze public bulk transcriptomic d…

article 2023
Uterine Natural Killer Cells Modulate Endometrial Growth and Persistence in Endometriosis
·doi:10.1016/j.jri.2023.104054
preprint 2022
Applying a computational transcriptomics-based drug repositioning pipeline to identify therapeutic candidates for endometriosis
·doi:10.1101/2022.12.20.22283736

Abstract Endometriosis is a common, inflammatory pain disorder comprised of disease in the pelvis and abnormal uterine lining and ovarian function that affects ∼200 million women of reproductive age worldwide and up to 50% of those with pel…