Edgardo Somigliana

Moreira and Oliveira highlight the shortcomings of the current management of endometriosis symptoms based on exclusively lesion-centred models, and promote patient categorisation according to an individual's predominant neurobiological mech…

BACKGROUND: In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA methylation (DNAm) patt…

BACKGROUND: Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure t…

STUDY QUESTION: What is the evidence available concerning gut and reproductive tract microbiomes in patients with endometriosis and what are the methodological approaches employed in microbiome studies on endometriosis? SUMMARY ANSWER: The…

Abstract Study question What is the prevalence of endometrial polyps in women with endometriosis and vice versa? Summary answer Available data showed that there is a bidirectional association between endometriosis and endometrial polyps, pa…

Abstract Study question Is IVF more effective than surgery for treating infertility associated to ovarian and deep endometriosis detected at ultrasound? Summary answer The live birth rate within a year from the study’s beginning was signifi…

BACKGROUND: Early reports from the beginning of this century highlighted significant ovarian damage following laparoscopic stripping of endometriomas. During the last 2 decades, the raised awareness of the possible detrimental effects of su…

Abstract Study question Does endometriosis affect the cumulative live birth rate in patients undergoing IVF compared to matched controls? Summary answer The cumulative live birth rates of patients with endometriosis are comparable to those …

Abstract Study question Do umbilical vein cord blood hormonal levels differ among pregnant women with endometriosis, polycystic ovarian syndrome (PCOS), and healthy controls delivering singleton female infants? Summary answer Umbilical cord…

OBJECTIVE: To investigate the prevalence of coexisting pelvic lesions in postcesarean bladder endometriosis (BE) and primary BE. If women with postcesarean BE exhibit a lower prevalence of coexistent endometriosis, it could be hypothesized …

STUDY QUESTION: In patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS; population), is the presence of functional endometrium (FE) in uterine remnants (URs) (exposure), compared with the absence of FE in UR/absence of UR (comparis…

The use of hormonal treatments for endometriosis has increased in recent years. Their effectiveness lies in creating a stable hormonal environment, reducing peripheral estrogen levels, and suppressing ovulation and menstruation. Although th…

RESEARCH QUESTION: What is the rate of second children among women affected from endometriosis who conceived their first child through Assisted Reproduction Technologies (ARTs)? Are there differences between endometriosis and other causes o…

Endometriosis affects women of reproductive age. Increasing attention is being given to the characterization of comorbidities in endometriosis to enhance clinical phenotyping. Among these comorbidities, migraine has been reported to be sign…

Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical kn…

Research rarely progresses in a straight line. It is more like an unpredictable front, marked by bursts of brilliance that fade after a few years, sudden breakthroughs, periods of stagnation, rediscoveries of forgotten ideas and occasional …

Linked article: This Correspondence comments on Knez et al. Click here to view the article.

BACKGROUND: No conceptually new drugs for the safe and successful cure of endometriosis are likely to become available soon. Hormonal modulation of ovarian function and suppression of menstruation remain the pillars of disease control. Howe…

This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and the negative impact on women's quality of life. Furthermore, advancement in our understanding of this…

IMPORTANCE: Evidence suggests that aberrant uterine contractility in nonpregnant women with endometriosis and adenomyosis contributes to symptoms and potentially heralds their pathogenesis. However, uterine peristalsis remains understudied,…