Zhang C

This study investigates the role of carbohydrate antigen 125 (CA125) in the pathogenesis of systemic lupus erythematosus (SLE) and analyzes factors associated with its elevation. A total of 220 patients diagnosed with SLE at the Department …

Ovarian cancer (OC) is a leading cause of gynecologic cancer mortality, with survival prediction limited by existing prognostic models that fail to capture tumor heterogeneity. Conventional methods lack precision for individualized risk ass…

Endometriosis is a common gynecological disease associated with pelvic pain and infertility. Despite several existing theories, the etiology and molecular mechanisms of endometriosis remain to be investigated. Here we report that transcript…

Infertility is a complex and sensitive phenomenon experienced by many couples worldwide. Our study investigated the causal effects of 486 serum metabolites on infertility using a Mendelian randomization (MR) approach, providing insights int…

The rapid advances in epigenetic and epitranscriptomic regulatory mechanisms have opened new prospects for precision therapies in various diseases. N-acetyltransferase 10 (NAT10) is currently the only known eukaryotic RNA ac4C acetyltransfe…

The female immune system operates within an evolutionary stability-plasticity trade-off, where the physiological demands of pregnancy necessitate a considerable degree of regulatory T cell (Treg) plasticity. This essential flexibility, howe…

BACKGROUND: Diminished ovarian reserve (DOR) is defined as the decline in both quantity and quality of oocytes in the ovarian cortex. In recent years, DOR has shown an increasing trend among young women. However, the specific etiology and d…

INTRODUCTION: Hydrosalpinx is one of the common organic causes of infertility, and the accumulation of fluid in this condition can severely affect embryo implantation and development. MATERIAL AND METHODS: We collected fallopian tube fluid…

ObjectiveTo evaluate whether vitamin D supplementation improves live birth rates in women with polycystic ovary syndrome undergoing in vitro fertilisation.DesignMulticentre, double blind, placebo controlled, randomised clinical trial.Settin…

BACKGROUND: Uterine cystic adenomyosis is a rare form of focal adenomyosis that is primarily located within the myometrium. In this case report, we present a unique case of adult uterine cystic adenomyosis found outside the uterus following…

INTRODUCTION: This study aimed to explore the feasibility and safety of robotic single port vaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) hysterectomy when compared with traditional vaginal natural orifice translumina…

BACKGROUND: Copy number variations (CNVs) of uncertain significance (VUS) are increasingly identified through prenatal and postnatal genetic testing, yet their clinical interpretation remains challenging. We report a neonate with hematologi…

OBJECTIVE: To identify if there is a high-risk group for chronic endometritis (CE) in infertile women. METHODS: A retrospective single-center cohort study was conducted on 209 infertile women with CE and 843 women without. Both univariate …

BACKGROUND: The levonorgestrel intrauterine system (LNG-IUS) may have its contraceptive or therapeutic efficacy compromised if displacement or expulsion occurs. By suturing and securing the device to the uterine wall, the risk of expulsion …

BACKGROUND: Lung cancer is a prevalent form of cancer worldwide, presenting a substantial risk to human well-being. Lung cancer is classified into two main types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). The adv…

BACKGROUND: Carotenoids, known for their antioxidant properties and potential health benefits, have attracted considerable attention. Nonetheless, the association between carotenoid levels and gallstone prevalence has not been adequately ex…

OBJECTIVE: To investigate the clinical features of bladder endometriosis and factors associated with urinary symptoms, pregnancy outcomes, and long-term effects of symptom relief and recurrence. DESIGN: A single-center retrospective cohort…

BACKGROUND: Existing biomarkers for epithelial ovarian cancer (EOC) have demonstrated limited sensitivity and specificity. This study aimed to investigate plasma protein and metabolite characteristics of EOC and identify novel biomarker can…

OBJECTIVES: The aim of this study was to assess the clinical outcomes of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) in patients with breast fibroadenoma (FA) of different sizes. MATERIALS AND METHODS: A total of 88 pat…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic condition in reproductive-aged women, linked to infertility and long-term cardiometabolic risk. Early identification remains challenging because current diagnosis …

The immunofluorescence assay is widely used for cellular biology and diagnosis applications. Such an antigen-antibody detection system enables the assessment and visualization of the expression and localization of target proteins. In the cl…

Endometriosis, a complex gynecological disorder characterized by aberrant growth of endometrial tissue outside the uterine cavity, poses a significant challenge to women's health. Emerging evidence implicates environmental pollutants, parti…

Di(2-ethylhexyl) phthalate (DEHP), the most prevalent plasticizer worldwide, can enter the human body via various exposure pathways, including ingestion, inhalation, skin contact, and medical applications. It has been observed to exhibit ch…

BACKGROUND: While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an at…