Vargheese Chennathukuzhi

ORCID: 0000-0002-4178-146X · 6 papers in corpus
preprint 2026
RE-1 silencing transcription factor is reduced in endometriosis and uterine deletion in mice alters progesterone responsiveness
bioRxiv : the preprint server for biology ·doi:10.64898/2026.05.30.728827

UNLABELLED: Endometriosis is a steroid-dependent gynecologic disease characterized by progesterone (P4) resistance, subfertility/infertility, and pelvic pain; however, the molecular mechanisms underlying impaired P4 responsiveness in endome…

article 2025
A MOUSE MODEL OF UTERINE TRAUMA ALTERS EXPRESSION OF A REST-MMP PATHWAY AND IS ASSOCIATED WITH DEVELOPMENT OF ADENOMYOSIS
·doi:10.1016/j.fertnstert.2025.07.587
2025
Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice.
PNAS nexus ·doi:10.1093/pnasnexus/pgaf024

Successful embryo implantation requires coordinated changes in the uterine luminal epithelium, including structural adaptations, apical-basal polarity shifts, intrauterine fluid resorption, and cellular communication. Planar cell polarity p…

other 2025
The molecular role of RE1 silencing transcription factor in uterine diseases: is there potential for targeted therapeutic development?
Expert opinion on therapeutic targets ·doi:10.1080/14728222.2025.2557280
preprint 2024
Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis
·doi:10.1101/2024.09.09.612036

ABSTRACT Uterine fibroids (leiomyomas), benign tumors of the myometrial smooth muscle layer, are present in over 75% of women, often causing severe pain, menorrhagia and reproductive dysfunction. The molecular pathogenesis of fibroids is po…

article 2024
Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice
·doi:10.1530/rep-24-0344

In brief: PRICKLE1, a WNT/planar cell polarity (PCP) protein that is downregulated in uterine leiomyoma, plays an important role in myometrial tissue architecture and extracellular matrix (ECM) deposition. This paper shows that myometrial-s…