Bruno Le Bizec

No ORCID on file · 12 papers in corpus
article 2025
O-034 Gaining insight into the chemical exposome of deep endometriosis using metabolomics
·doi:10.1093/humrep/deaf097.034

Abstract Study question Do environmental chemicals play a role on deep endometriosis through metabolic disruption? Summary answer The present study support that women with deep endometriosis exhibit a specific metabolic profile associated t…

article 2024
A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor
The Science of the total environment ·doi:10.1016/j.scitotenv.2024.170678

BACKGROUND: Exposure to persistent organic pollutants (POPs) has been related to the risk of endometriosis however the mechanisms remain unclear. The objective of the present study was to characterize the metabolic profiles underpinning the…

review 2021
Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence
Environmental health perspectives ·doi:10.1289/ehp8421

BACKGROUND: -dioxin (TCDD), may play a role in the pathogenesis of endometriosis. OBJECTIVES: ) on the associations between exposure to OCCs and endometriosis-related end points. METHODS: evidence further supported the roles of the aryl hyd…

article 2021
Associations between persistent organic pollutants and endometriosis: A multiblock approach integrating metabolic and cytokine profiling
Environment international ·doi:10.1016/j.envint.2021.106926

Humans are exposed daily to complex mixtures of chemical pollutants through their environment and diet, some of which have the potential to disrupt the bodies' natural endocrine functions and contribute to reproductive diseases like endomet…

article 2020
Associations between persistent organic pollutants and endometriosis: A multipollutant assessment using machine learning algorithms
Environmental pollution (Barking, Essex : 1987) ·doi:10.1016/j.envpol.2020.114066

Endometriosis is a gynaecological disease characterised by the presence of endometriotic tissue outside of the uterus impacting a significant fraction of women of childbearing age. Evidence from epidemiological studies suggests a relationsh…

article 2020
Linking biomarkersof environmental chemical exposure and endometriosis: integrating the exposome and metabolome in the ENDOXOMICS-b Study
·doi:10.1289/isee.2020.virtual.o-os-965

Background/Aim Endometriosis is a gynaecological disease impacting a staggering 5-15% of women with dramatic socio-economic impacts, aggravated by long diagnostic delays of 8-10 years between symptom onset and surgical confirmation. Previou…

other 2019
Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol
Environment international ·doi:10.1016/j.envint.2018.12.063

BACKGROUND: Endometriosis is a hormone-dependent gynaecological disease characterised by the presence and growth of endometrial tissues outside of the uterus. There is growing experimental evidence that suggests environmental endocrine disr…

meta-analysis 2019
Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis
Environment international ·doi:10.1016/j.envint.2018.11.065

BACKGROUND: Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue that affects women during their reproductive years, having a strong impact on their lives, fertility and healthcare costs. The…

article 2018
The challenging use and interpretation of circulating biomarkers of exposure to persistent organic pollutants in environmental health: Comparison of lipid adjustment approaches in a case study related to endometriosis
Chemosphere ·doi:10.1016/j.chemosphere.2018.02.120

The gold-standard matrix for measuring the internal levels of persistent organic pollutants (POPs) is the adipose tissue, however in epidemiological studies the use of serum is preferred due to the low cost and higher accessibility. The int…

article 2017
Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma
Environment international ·doi:10.1016/j.envint.2017.08.019

Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue. Histologically, it appears as different sub-types, being peritoneal endometriosis, ovarian endometrioma (OvE) and deep infiltrating endom…

article 2016
Distribution of persistent organic pollutants in serum, omental, and parietal adipose tissue of French women with deep infiltrating endometriosis and circulating versus stored ratio as new marker of exposure
Environment international ·doi:10.1016/j.envint.2016.08.011

Several studies have assessed the potential role of environmental chemicals in the onset, growth, and/or physiopathology of endometriosis. However, their contour in terms of considered exposure markers remains limited. The present study aim…

2016
EPMA-World Congress 2015 : Bonn, Germany. 3-5 September 2015
The EPMA journal

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access app…