Shibutani Y

No ORCID on file · 5 papers in corpus · active 1997-1999

Study types

  • article 5

Condition tags

  • endometriosis 3
article 1999
European journal of pharmacology ·doi:10.1016/s0014-2999(99)00765-7

Orally administered dienogest (17alpha-cyanomethyl-17beta-hydroxy-estra-4,9-diene-3-one) is efficacious against human hormone-dependent cancer xenografts in severely immunodeficient mice and in rats with experimental endometriosis, but its …

article 1999
Toxicology letters ·doi:10.1016/s0378-4274(98)00354-3

We investigated the effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats compared with that of medroxyprogesterone acetate (MPA) and danazol, in order to elucidate the reason for relativel…

article 1998
European journal of endocrinology ·doi:10.1530/eje.0.1380216

OBJECTIVE: Dienogest, a synthetic steroid with progestational activity, is used as a component of oral contraceptives and is currently being evaluated clinically for the treatment of endometriosis. The present study was conducted to confirm…

article 1997
Drugs under experimental and clinical research

Dienogest is an orally active synthetic steroid that is used for contraception and is currently being studied for the possible treatment of endometriosis. Earlier we demonstrated that dienogest had therapeutic effects on experimental endome…

article 1997
Cancer ·doi:10.1002/(sici)1097-0142(19970101)79:1<169::aid-cncr24>3.0.co;2-1

BACKGROUND: Dienogest is a synthetic progestational steroid that is used for contraception. It is being studied for the treatment of endometriosis, but its anticancer activity remains unknown. The authors investigated the anticancer effect …