Huang S

Mitochondrial dysfunction has been demonstrated with a role in pathologically driving various obstetric and gynecological (OB/GYN) diseases, but molecular mediators associating mitochondrial dysfunction with discrete pathologies have not be…

Ovarian cancer is one of the leading causes of gynecologic cancer-related mortality in women. However, a significant proportion of ovarian cancer cases are only detected at an advanced stage (III or IV) and are complicated to treat because …

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare aggressive, and chemo-resistant subtype of epithelial ovarian cancer. Current limitations in precisely characterizing its molecular features have resulted in restricted availability …

OBJECTIVE: To investigate the effect of bisphosphonates on surgical site infection (SSI) and their safety in postmenopausal women undergoing Anterior Cervical Discectomy and Fusion (ACDF). METHODS: This was a single-center retrospective coh…

INTRODUCTION: Embryonic stem cells (ESCs), capable of generating all adult cell types, hold transformative potential for agriculture and biomedicine. However, stable sheep ESCs derivation remains challenging, limiting their application in f…

BACKGROUND: As the global population ages, pancreatitis in older adults has become a public health issue. Nonetheless, detailed information on its global impact and changing patterns is limited. We sought to explore the epidemiological tren…

Qiu Meng,1 Xingrun Xie,2 Haiyan Wang,1 Shouguo Huang,1 Jie Wang,1 Jiantao Fu,1 Jing Zhang11Department of Obstetrics and Gynecology, Haikou People’s Hospital, The First Affiliated Hospital of Hainan University, Haikou, 570208, People’s Repub…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent disease that can lead to chronic pain and infertility. Small ubiquitin-related modifier (SUMO)ylation, a key post-translational modification, has been demonstrated to be associated wi…

Endometriosis (EMs) is a prevalent gynecological disorder affecting reproductive-age women. Exosomes secreted by peripheral blood macrophages may participate in EMs progression. In this pilot translational study, exosomes from peripheral bl…

BACKGROUND: Elevated maternal body mass index (BMI) increases miscarriage risk in assisted reproductive technology, but it is unclear whether this risk differs between singleton and twin pregnancies. Twin gestations impose greater metabolic…

BACKGROUND: Endometriosis is a chronic inflammatory disease linked to infertility. Coagulation-related processes may contribute to lesion persistence and pelvic remodeling, but the relevance of coagulation parameters in women with infertili…

The human gut microbiome is a cornerstone of health, yet conventional probiotic therapies often exhibit limited efficacy owing to heterogeneity in host-microbe-environment dynamics. This review dissects the biological and environmental driv…

BACKGROUND: Ovarian pregnancies at advanced gestational ages are exceedingly rare in clinical practice. The infrequency of this condition, coupled with the nonspecific nature of its symptoms and signs, renders preoperative diagnosis extreme…

INTRODUCTION: Accurate and non-invasive assessment of early embryonic metabolic biomarkers and their association with developmental potential remains a major challenge in assisted reproductive technology (ART). Glucose is a key metabolic co…

Filamentous fungi exhibit high heavy metal resistance; elucidating their resistance mechanisms is of practical importance for fungal utilization and for engineering other microorganisms. However, the molecular basis of copper tolerance in f…

The extraction methods of berberine hydrochloride include water, acidified water, lime milk, and ethanol extraction. The water extraction method is mainly a decoction method, whereas the alcohol extraction method mainly includes microwave, …

BACKGROUND: Although the dietary inflammatory index (DII) plays a vital role in human health, the association between the DII and women's menopausal status is still unclear. The aim of this study was to investigate the associations of the e…

BACKGROUND: Female infertility is a global health issue, with metabolic disorders emerging as significant contributors. Liver steatosis, characterized by excessive hepatic fat accumulation, is closely linked to metabolic dysfunction and may…

OBJECTIVE: To develop and validate a diagnostic nomogram model for predicting atypical endometrial hyperplasia (AEH) and endometrial carcinoma (EC) in women aged 40-60 years with abnormal uterine bleeding (AUB), incorporating detailed bleed…

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinS…

This study aims to systematically review and evaluate the quality of clinical research on the treatment of adenomyosis(AM) with traditional Chinese medicine(TCM) in recent ten years, using evidence graphs. Computer searches were conducted o…

BACKGROUND: The human body's intestinal microbiota is a vital "organ" that coexists with it and is intimately linked to both human health and illness. Human intestinal microbiota and its metabolites are a crucial component in the developmen…

BACKGROUND: Endometriosis is a chronic inflammatory gynecological disease. Previous studies have explored relationships between endometriosis and the microbiota, but none have focused on differences in gut microbiota between early-stage and…

Ovarian cancer is the second most common gynecologic malignancy in the United States, with high mortality due to delayed diagnosis. Serum CA-125 is widely used for screening and monitoring but lacks sensitivity and specificity in some cases…