OBJECTIVE: To study the association between gene polymorphisms of cytochrome P450 1B1 (CYP1B1) in exon 2 codon 119 (G-T) and exon 3 codon 432 (C-G) and the susceptibility to endometriosis. METHODS: Allele-specific polymerase chain reaction…
We recently demonstrated mitochondrial localization of estrogen receptor beta (ERbeta). We herein confirm the mitochondrial localization of ERbeta by the loss of mitochondrial ERbeta immunoreactivity in ERbeta knockdown cells. A phenotype c…
OBJECTIVE: To evaluate the therapeutic effect of quercetin on the rat endometriosis models and the relationship between the inhibition effect and the expression of HSP70 and VEGF. METHODS: A surgical model to simulate endometriosis was est…
OBJECTIVE: To explore novel endometriosis serum biomarkers by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS). DESIGN: First, we aimed to discover the potential biomarkers of endometriosis by SE…
OBJECTIVE: To identify the differently expressed proteins in adenomyotic tissue compared with normal uterine muscle. DESIGN: Retrospective, case-controlled study. SETTING: University-based Department of Obstetrics and Gynecology and Prote…
Endometriosis, defined as the presence of endometrial glandular and stromal cells outside the uterine cavity, is a common gynecological disease with poorly understood pathogenesis. Using laser capture microdissection and a cDNA microarray w…
OBJECTIVE: To study the possibility of a correlation between occurrence of endometriosis (EM) and polymorphism of human leukocyte antigen (HLA) DRB1 allele. METHODS: Polymorphism of HLA-DRB1 allele were detected by polymerase chain reactio…
OBJECTIVE: To study the possibility of a correlation between polymorphism of human leukocyte antigen (HLA)-I antigen and occurrence of endometriosis (Em). METHODS: Polymorphism of HLA-I A and B locations were detected by mini-lymphocytotox…
OBJECTIVE: To investigate the abnormal distribution of lymphocytes in eutopic and ectopic endometrium of patients with endometriosis and its significance. METHODS: In 43 cases, biopsies of ectopic tissues were taken by laparoscopy and lapa…