Tiwari-Woodruff SK

No ORCID on file · 2 papers in corpus · active 2016-2019
2019
Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis.
Scientific reports ·doi:10.1038/s41598-018-37420-x

Pharmaceutical agents currently approved for the treatment of multiple sclerosis reduce relapse rates, but do not reverse or prevent neurodegeneration nor initiate myelin repair. The highly selective estrogen receptor (ER) β ligand chloroin…

2016
Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: Estrogen receptor ligand effects.
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2016.01.006

Demyelination in multiple sclerosis (MS) leads to significant, progressive axonal and neuronal degeneration. Currently existing immunosuppressive and immunomodulatory therapies alleviate MS symptoms and slow, but fail to prevent or reverse,…