Mathew Leonardi

BACKGROUND: Endometriosis is a chronic disease characterized by endometrial-like tissue outside the uterus. Superficial endometriosis (SE) is the most prevalent form, yet it remains underdiagnosed due to subtle clinical and imaging presenta…

Diagnostic delay is a significant issue facing people with endometriosis; however, the Australian perspective and participant voice is missing for why delay occurs. The current study aimed to assess the length of diagnostic delay, whether t…

OBJECTIVES: Accurate diagnosis of pathology from ultrasound images is reliant upon images of a suitable diagnostic quality being acquired. This study aimed to create a novel machine learning model to automatically assess transvaginal ultras…

OBJECTIVE: To evaluate the diagnostic accuracy of transvaginal ultrasonography (TVUS) in detecting deep endometriosis, ovarian endometriosis, and superficial endometriosis using the IDEA (International Deep Endometriosis Analysis) consensus…

STUDY OBJECTIVE: To examine endometriosis-related content on Instagram, a platform increasingly used for health communication, to understand: 1) the identity of Instagram content creators; 2) themes, tones, and emotions evoked from posts; a…

OBJECTIVE: To assess the impact of complex disease states, including pouch of Douglas (POD) obliteration and deep endometriosis (DE) of the bowel, on the diagnostic accuracy of transvaginal ultrasound (TVUS) for detecting endometriosis of t…

BACKGROUND: Inter-observer agreement for the American Association of Gynecologic Laparoscopists (AAGL) 2021 Endometriosis Classification staging system has not been described. Its predecessor staging system, the revised American Society for…

OBJECTIVES: The development of valuable artificial intelligence (AI) tools to assist with ultrasound diagnosis depends on algorithms developed using high-quality data. This study aimed to test the intra- and interobserver agreement of a pro…

BACKGROUND: Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease …

OBJECTIVE: To identify a microbial signature for endometriosis for use as a diagnostic non-invasive biomarker. DESIGN: Prospective cohort pilot study. SETTING: Nepean Hospital and UNSW Microbiome Research Centre, Australia. POPULATION: S…

ABSTRACT Objective: To explore diagnostic preferences among individuals with confirmed or suspected endometriosis to inform the development of patient-centered diagnostic strategies. Design: Qualitative study using semi-structured focus gro…

INTRODUCTION: Understanding what patients prioritize when seeking care for endometriosis and chronic pelvic pain (CPP) is crucial for delivering personalized, responsive care. However, patient-defined goals remain poorly characterized acros…

ObjectiveAdhesions between the uterus, bladder and anterior abdominal wall are associated with clinical sequelae, including chronic pelvic pain and dyspareunia, and can also yield complications during surgery. The transvaginal sonographic (…

Abstract BACKGROUND Patients with endometriosis experience chronic, inflammatory symptoms including severe pelvic pain and infertility, caused by endometrial-like tissue growth outside the uterus. Endometriosis remains poorly understood, la…

BACKGROUND: Endometriosis is prevalent in approximately 6-10% of all women of reproductive age and is associated with pelvic pain, heavy menstrual bleeding, infertility, and pain during intercourse. Despite reporting symptoms, women wait ar…

INTRODUCTION: Endometriosis is a chronic inflammatory condition that affects around 1 in 7 women of reproductive age. Current medical treatments tend to be sub-optimal to manage the range of symptoms, with low levels of patient satisfaction…

OBJECTIVES: Endometriosis ultrasound is an accurate, cost-effective, and non-invasive diagnostic tool that can help improve the diagnostic delay that patients with endometriosis experience. As an emerging diagnostic method, the perspectives…

Endometriosis is a chronic condition where tissue resembling the uterine lining grows elsewhere in the pelvis, often causing pain, infertility, and inflammation. For decades, textbooks and research papers have described the rectovaginal sep…

• High prevalence of severe dysmenorrhea in patients with PCOM. • Heavy menstrual flow strongly predicts severe dysmenorrhea. • Gravidity appears protective against severe menstrual pain. • PCOM identified in nearly 20% of gynecologic ultra…

Endometriosis is a serious multifocal condition that can involve various pelvic structures, with Pouch of Douglas (POD) obliteration being a significant clinical indicator for diagnosis. To circumvent the need for invasive diagnostic proced…

• Diagnostic Challenge: Ovarian endometriomas have a characteristic ultrasound appearance but can be mimicked by various ovarian and non-ovarian pathologies. • Intraoperative Ultrasound Findings: A new cystic lesion with a ‘ground glass’ ap…

OBJECTIVE: Vaginal endometriosis occurs in 3.5% to 14.5% of patients with endometriosis [1-3]. Complete resection is crucial, as unnecessary colpotomy may increase the risk of rectovaginal fistula [4], and incomplete resection may leave res…