Ryoichi Asaka

No ORCID on file · 6 papers in corpus · active 2016-2023

Study types

  • other 2
  • article 1

Condition tags

  • endometriosis 3
article 2023
Scientific reports ·doi:10.1038/s41598-023-35292-4

Although endometriosis is primarily benign, it has been identified as a risk factor for endometriosis-associated ovarian cancer (EAOC). Genetic alterations in ARID1A, PTEN, and PIK3CA have been reported in EAOC; however, an appropriate EAOC…

2021
Laboratory investigation; a journal of technical methods and pathology ·doi:10.1038/s41374-021-00624-3

Endometrium-related malignancies including uterine endometrioid carcinoma, ovarian clear cell carcinoma and ovarian endometrioid carcinoma are major types of gynecologic cancer, claiming more than 13,000 women's lives annually in the United…

2018
Clinical cancer research : an official journal of the American Association for Cancer Research ·doi:10.1158/1078-0432.ccr-18-1199

PurposeHigh-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess …

other 2017
Applied immunohistochemistry & molecular morphology : AIMM ·doi:10.1097/PAI.0000000000000316

Sirtuin 1 (SIRT1), originally identified as a longevity gene, regulates DNA repair and metabolism by deacetylating target proteins such as p53. SIRT1 plays a key role in the pathophysiology of metabolic diseases and neurodegenerative disord…

2017
Translational oncology ·doi:10.1016/j.tranon.2017.05.005

BackgroundSIRT1 is a longevity gene that forestalls aging and age-related diseases including cancer, and has recently attracted widespread attention due to its overexpression in some cancers. We previously identified the overexpression of S…

other 2016
Free radical research ·doi:10.3109/10715762.2015.1134795

Ovarian clear cell carcinoma (CCC) arises from ovarian endometriosis. Intra-cystic fluid contains abundant amounts of free iron, which causes persistent oxidative stress, a factor that has been suggested to induce malignant transformation. …