Wu C

ObjectiveThis study aimed to provide guidance for couples in dietary adjustments to optimize trace element concentrations for improved fertility and to offer a reference for formulating precise reproductive health policies.DesignIn this pro…

BackgroundAtrial fibrillation (AF) and ovarian cancer are leading causes of morbidity, with emerging evidence suggesting potential interplay. However, their temporal and genetic relationships remain unclear.MethodsWe analyzed 265,248 women …

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

PurposeTo investigate the hypothesis that an imbalance between the epithelial adhesion molecule E-cadherin and matrix metalloproteinases (MMPs) underlies the vaginal atrophy associated with menopause.MethodsThis cross-sectional study includ…

BackgroundThe impact of the interval between consecutive testicular sperm aspiration (TESA) procedures on pregnancy outcomes of intracytoplasmic sperm injection (ICSI) in patients with obstructive azoospermia (OA) remains controversial. Thi…

OBJECTIVE: This study investigates the therapeutic potential of low-molecular-weight heparin (LMWH) in acute pancreatitis (AP), focusing on its effects on lipid metabolism, inflammatory responses, and pancreatic tissue integrity. The study …

The significance of multi-combination machine learning models utilizing vision transformer (VIT) features in forecasting pathological complete response (pCR) after breast cancer neoadjuvant therapy (NAT). A retrospective study was conducted…

Purpose: Uterine corpus endometrial carcinoma (UCEC) is a gynecological malignancy with poor prognosis and high lethality rates. Pyroptosis, a pro-inflammatory programmed cell death pattern, significantly influences tumor growth, developmen…

ObjectiveThis study aims to evaluate the risk factors of residual/recurrent lesions of cervical intraepithelial neoplasia 2/3 (CIN2/3) in patients who underwent cold-knife conization (CKC).MethodsA total of 976 patients with CIN2/3 who were…

BackgroundGynecological diseases significantly impact the reproductive health in women of childbearing age (WCBA). However, there is currently a lack of analysis on the specific burden and forecast of common gynecological diseases for this …

We report the case of a woman in her early 30 s who was diagnosed with Robert's uterus. She had been experiencing progressive dysmenorrhea for a decade and sought treatment for infertility at our hospital. Preoperative ultrasound imaging re…

Prostaglandin E2 (PGE2) signaling through EP2 and EP4 receptors is crucial in regulating inflammation, pain, and cancer progression. While selective and dual antagonists for these receptors hold therapeutic potential, their binding mechanis…

OBJECTIVE: In the present study, a bidirectional two-sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA-CN) and ovary-related reproductive disorders (O…

Autoimmune pancreatitis (AIP) is identified as a severe chronic immune-related disorder in pancreas, including two subtypes. In this study, pancreatic lesions in patients diagnosed as either type 1 AIP or type 2 AIP are examined, and these …

BackgroundIntrauterine adhesions (IUAs) are a significant clinical challenge, affecting reproductive health and leading to infertility or recurrent pregnancy loss. Understanding the molecular mechanisms underlying IUA prevention is crucial …

BackgroundAlthough studies on the effects of diet on fertility has progressed, some cumulative evidence has piled against popular hypotheses. The aim of our study was to investigate the effects of 31 diets including 23 individual dietary in…

BACKGROUND: Although gynecological health issues are common and cause considerable distress, little is known about their causes. We examined how birth history is associated with urinary incontinence (UI), severe period pain, heavy periods, …

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, …

Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically characterize human ovarian aging. S…

BACKGROUND: Endometriosis is considered as a systemic disease with the presence of proinflammatory cytokines in the circulation, which drives hypercoagulable state of endometriosis. Currently, endometriosis is classified into four stages: I…

Abstract Background Endometriosis is considered as a systemic disease with the presence of proinflammatory cytokines in the circulation, which drives hypercoagulable state. Currently, endometriosis is classified into four stages: I (minimal…

PurposeTo compare the safety, feasibility, and effectiveness of transvaginal natural orifice transluminal endoscopic sacrocolpopexy (vNOTES-SC) and laparoendoscopic single-site sacrocolpopexy (LESS-SC) for pelvic organ prolapse (POP).Method…

Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) is very safe and has a high diagnostic rate for upper gastrointestinal lesions, especially pancreatic lesions, but its application in the lower gastrointestinal tract …

BackgroundRecent studies have reported higher risks of adverse maternal and neonatal outcomes, such as hypertensive disorders of pregnancy, after programmed frozen embryo transfer, especially in cycles with gonadotropin-releasing hormone ag…

BackgroundShift work is a potential risk factor for women's reproductive health. Evidence suggests that shift work is associated with menstrual disorders, reproductive disturbances, and adverse pregnancy outcomes. However, previous studies …