Chen Y

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the in…

PURPOSE: Emerging evidence suggests that an abnormal endometrial microbiota may be a potential factor contributing to recurrent pregnancy loss (RPL). This study aimed to characterize the endometrial microbiota in patients with RPL and to ex…

Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity…

Cancer remains the leading cause of mortality worldwide, and the emergence of drug resistance has made the identification of new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct of glycolysis with limited ATP-pro…

High incidence of unexplained miscarriage (UM) limits global human reproduction. Lithium (Li) batteries are widely used but rarely recycled, causing Li to spread into environments and enter human body. Notably, the healthy effects of Li exp…

BACKGROUND: Human Papillomavirus (HPV) infection is a ubiquitous sexually transmitted infection globally, frequently associated with sexual behaviors characterized by increased frequency and multiple partnerships. The relationship between v…

Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cause, as not all affected women develop EMs. Emerging evidence suggests a significant association between the vaginal mi…

OBJECTIVES: To investigate the mechanism of medicinal cake-separated moxibustion in inhibiting the adhesion, invasion and angiogenesis of ectopic endometriotic tissues in endometriosis (EMs) rats through transforming growth factor-β1 (TGF-β…

OBJECTIVE: This study aimed to investigate the microbiome profile in the cystic fluid of ovarian endometrioma and explore its association with the microbial communities present in the lower and upper reproductive tracts. DESIGN: A microbia…

BACKGROUND: Comprehensive sonographic evaluation of pre- and postmenopausal women with abnormal uterine bleeding is essential for accurate diagnosis and the optimization of curative outcomes for endometrial malignancy. Microvascular flow im…

MicroRNAs play crucial roles in regulating inflammatory responses and disease progression. Since its identification on chromosome 17q11.2 in 2005, miR-451 has emerged as a key regulator of multiple physiological and pathological processes. …

Cuproptosis, a copper-dependent distinct form of cell death, holds a critical role in tumor development. However, further investigation is needed to elucidate the impact of the cuproptosis signaling on thyroid cancer. In this study, compreh…

Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide association studies of erectile dysfunction in AllofUs subjects of European and African an…

Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here,…

Safflower (Carthamus tinctorius L.), also known as Honghua, blueflower, or prickly safflower, is a medicinal herb effective in promoting blood circulation, dredging meridians, eliminating blood stasis, and relieving pain. Safflower contains…

Objective To identify novel and noninvasive biomarkers for the diagnosis of adenomyosis and to provide potential therapeutic targets. Design We conducted a cross-sectional study using data from 110 women of reproductive age who underwent pe…

Endometriosis is a hormone dependent disease that often accompanies infertility. At present, the incidence rate of endometriosis is on the rise, but its pathogenesis and the mechanism leading to fertility reduction are still unclear. Here, …

OBJECTIVE: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). O…

BACKGROUND: Many components in follicular fluid (FF), such as peptide hormones, cytokines, and steroids, undergo dynamic changes during folliculogenesis and have important roles in follicular development. Because systemic inflammation has a…

Endometrial fibrosis can lead to uterine infertility. Accurate staging of endometrial fibrosis is crucial for developing treatment plans and performing dynamic follow-ups. This study aimed to evaluate the feasibility of radiomics models bas…

BACKGROUND: The quality of in vitro matured (IVM) oocytes remains inferior to that of in vivo matured oocytes, likely due to DNA damage induced by the in vitro environment. Although rapamycin has been shown to improve the developmental comp…

Minimally invasive gynecologic surgery (MIGS) has changed gynecologic care over the past thirty years by introducing techniques like multiport laparoscopy, robotic-assisted laparoscopy, and single-site surgery. MIGS offers advantages like r…

BACKGROUND Ventricular interdependence - mediated by shared pericardial and septal mechanics - can precipitate biventricular dysfunction during acute right ventricular (RV) volume overload. RV dilation impairs left ventricular (LV) complian…

BACKGROUND: The main characteristics of the robotic surgical system include high-definition three-dimensional imaging, flexible and stable instruments, and an ergonomic console design. Incorporating robotic systems with laparoendoscopic sin…

OBJECTIVE: This study aimed to explore the relationship between serum uric acid-to-serum creatinine (UA:SCr) ratio and thyroid function within the normal range and in gestational diabetes mellitus (GDM) during early pregnancy in Chinese wom…