Luke Grundy

No ORCID on file · 5 papers in corpus · active 2019-2021

Study types

  • article 4
  • review 1

Condition tags

  • endometriosis 5
  • chronic_pelvic_pain 4
  • infertility 2
  • irritable_bowel_syndrome 1
  • dyspareunia 1
article 2021
A mouse model of endometriosis that displays vaginal, colon, cutaneous, and bladder sensory comorbidities
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202002441r

Endometriosis is a painful inflammatory disorder affecting ~10% of women of reproductive age. Although chronic pelvic pain (CPP) remains the main symptom of endometriosis patients, adequate treatments for CPP are lacking. Animal models that…

article 2021
A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours
Pain ·doi:10.1097/j.pain.0000000000002552

ABSTRACT: Endometriosis is a chronic and debilitating condition, commonly characterised by chronic pelvic pain (CPP) and infertility. Chronic pelvic pain can be experienced across multiple pelvic organs, with comorbidities commonly effectin…

review 2020
Pain in Endometriosis
Frontiers in cellular neuroscience ·doi:10.3389/fncel.2020.590823

Endometriosis is a chronic and debilitating condition affecting ∼10% of women. Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options remain limited. In many respects this is related to an underlying la…

article 2020
Pharmacological modulation of voltage-gated sodium (NaV) channels alters nociception arising from the female reproductive tract
Pain ·doi:10.1097/j.pain.0000000000002036

Dyspareunia, also known as vaginal hyperalgesia, is a prevalent and debilitating symptom of gynaecological disorders such as endometriosis and vulvodynia. Despite this, the sensory pathways transmitting nociceptive information from female r…

article 2019
Linaclotide treatment reduces endometriosis-associated vaginal hyperalgesia and mechanical allodynia through viscerovisceral cross-talk
Pain ·doi:10.1097/j.pain.0000000000001657

Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat mode…