Zhang J

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

BACKGROUND: Endometrial receptivity (ER) serves as a critical determinant for successful embryo implantation, yet its molecular complexity and limited clinical assessment methods pose significant challenges. Despite advancements in assisted…

BACKGROUND: Immune tolerance breakdown at the maternal-fetal interface is implicated in unexplained recurrent pregnancy loss (URPL), but the interplay between T cell hyperactivation and dendritic cells (DCs)-mediated signaling remains poorl…

BACKGROUND: The impact of changes in estradiol (E2) levels prior to human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) on pregnancy and live birth outcomes remains poorly understood. OBJECTIV…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility. Despite a high antral follicle count, advanced-age PCOS patients experience a marked decline in cumulative live birth rates (CLBR) after assisted re…

BACKGROUND: This study investigates the clinical characteristics, treatment strategies, and prognosis of ovarian leiomyoma, with the goal of enhancing diagnostic accuracy and therapeutic outcomes for this rare condition. METHODS: We retrosp…

Panax ginseng C.A. Meyer, a renowned medicinal herb, exerts many of its systemic effects through intricate interactions with the gut microbiota, a relationship that also addresses the challenge of its own limited oral bioavailability. This …

PurposeOvarian clear cell carcinoma (OCCC) is frequently characterized by dysregulation of the PI3K/AKT/mTOR (PAM) pathway; however, the expression patterns and clinical significance of class I PI3K catalytic isoforms remain incompletely un…

Spinal cord injury (SCI) is a serious neurological system disease. After SCI, a series of cascade reactions can cause irreversible damage, with a high disability rate and mortality rate. The complexity of the pathological mechanism of SCI l…

BACKGROUND: Mixed gestational trophoblastic neoplasia (GTN) is an exceptionally rare form of GTN, characterized by the coexistence of choriocarcinoma (CC) and/or placental site trophoblastic tumor (PSTT) and/or epithelioid trophoblastic tum…

The human gut microbiome is a cornerstone of health, yet conventional probiotic therapies often exhibit limited efficacy owing to heterogeneity in host-microbe-environment dynamics. This review dissects the biological and environmental driv…

LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in fav…

BACKGROUND: Infertility affects many couples worldwide, and the accurate assessment of endometrial receptivity (ER) is critical. However, conventional ultrasound has limited predictive value. Multiparameter quantitative ultrasound is a prom…

Primary vaginal cancer is a rare malignant tumor; its pathogenesis remains unclear and only a limited number of cases have been documented in the literature. The present report outlines a rare case of primary vaginal endometrioid adenocarci…

BACKGROUND: To evaluate whether progesterone-induced changes in endometrial thickness (EMT) affect singleton infant outcomes during frozen-thawed embryo transfer (FET) cycles. METHODS: This retrospective study analyzed 6,331 singleton live…

BackgroundRecurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) are major causes of pathological early pregnancy, yet their mechanisms remain poorly understood. This study aimed to identify shared molecular mediators and t…

ObjectivesThis study investigated the protective effects and mechanisms of rhaponticin (Rha) against acinar cell injury in acute pancreatitis (AP).MethodsPancreatic acinar cell injury was induced using multiple in vitro and in vivo AP model…

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting reproductive-aged women and is associated with an increased risk of early pregnancy loss (EPL). The underlying mechanisms remain multifactorial and poorly understood.…

OBJECTIVE: To identify the risk factors associated with postoperative recurrence of unusual (special-type) uterine smooth muscle neoplasia (USMN) and to construct and interpret a machine-learning model for recurrence risk. METHODS: We carr…

Endometriosis is a chronic inflammatory disease with cancer-like features, yet the mechanisms linking metabolic dysregulation to immune remodeling during lesion progression remain poorly understood. Here, we identify the ubiquitin E3 ligase…

Cervical cancer has become a glaring concern for women's health globally. The use of single-cell RNA sequencing (scRNA-seq) contributes to a comprehensive understanding of cellular heterogeneity and the immune cell landscape in the TME of c…

Varicocele-induced decline in sperm quality is a common cause of male infertility. While varicocelectomy improves semen parameters, the mechanisms remain unclear. Recent studies suggested that small noncoding RNAs (sncRNAs) in sperm play a …

BACKGROUND: This study investigates how clinical factors and hormonal levels affect oocyte retrieval in modified natural cycles, aiming to improve understanding and enhance treatment protocols. METHODS: A retrospective analysis of data fro…

INTRODUCTION: Accurate and non-invasive assessment of early embryonic metabolic biomarkers and their association with developmental potential remains a major challenge in assisted reproductive technology (ART). Glucose is a key metabolic co…

Background: Acute cholecystitis (AC) is a common inflammatory disease of the gallbladder. Although laparoscopic cholecystectomy remains the standard treatment, gallbladder drainage may be required in patients who are unsuitable for early su…