Wu H

Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and the molecular mechanisms underlying endometrial receptivity are incompletely understood. This study aimed to comprehensively characteriz…

BackgroundWith the increasing rate of cesarean sections, long-term complications have received growing attention, and the cesarean scar diverticulum (CSD) is one of the 3 major complications of cesarean section. While rupture during pregnan…

BACKGROUND: Sperm DNA fragmentation index (DFI) has emerged as a potential marker of male fertility, but its clinical value in assisted reproductive technology (ART) remains debated. This study aimed to investigate the association between s…

BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of childbearing age. In addition, it is a heterogeneous disease with numerous etiologies, multiple levels, and uneven manifestation. In patients …

BACKGROUND: This study evaluated the effects of different ovulation trigger strategies on pregnancy outcomes in letrozole-stimulated and modified natural frozen–thawed embryo transfer (L-FET and mNC-FET) cycles. METHODS: A total of 2053 eli…

BackgroundLittle is known about the oncologic results of patients with low-grade endometrial stromal sarcoma (LGESS) with fertility preservation. This study investigated the prognosis of fertility-sparing surgeries and relevant obstetrical …

Hydrogels are highly hydrated three-dimensional polymeric network materials that have attracted considerable attention in medical and biomedical fields owing to their favorable chemical modifiability, physical tunability, biocompatibility, …

Abstract Hypoxia, a state of reduced oxygen availability, drives endometrial disease progression by inducing cellular reprogramming that promotes inflammation, angiogenesis, and aberrant cell survival in endometriosis and endometrial cance…

PurposeTo investigate the impact of storage duration after vitrification of cleavage-stage embryos on pregnancy and perinatal outcomes.MethodsA retrospective study was conducted on 4205 infertile patients underwent frozen-thawed embryo tran…

ObjectiveThis study aims to investigate the role and regulatory mechanisms of PTP1B in acute pancreatitis.MethodsAn in vitro AP cell model was established using Caerulin (CAE). Cells were subsequently treated with MSI-1436 (PTP1B inhibitor)…

OBJECTIVE: To perform a preliminary, hypothesis-generating evaluation of the association between intraovarian injection of platelet-rich plasma (PRP) combined with peripheral blood mononuclear cells (PBMCs) and ovarian response parameters i…

BackgroundDiminished ovarian reserve (DOR) is associated with impaired female fertility; however, its molecular mechanisms remain incompletely understood. Our previous studies found that individuals with DOR have lower levels of microRNA-37…

ObjectiveTo investigate oncological and reproductive outcomes in patients with mismatch repair-deficient (MMRd) endometrial endometrioid carcinoma (EEC) or atypical endometrial hyperplasia (AEH) undergoing fertility-preserving treatment to …

Globally, approximately 80-95% of women of reproductive age are affected by premenstrual syndrome and menstrual-related symptoms, which significantly impair their quality of life. Although non-steroidal anti-inflammatory drugs and hormonal …

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

BACKGROUND: Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an ass…

Endometriosis is a debilitating chronic inflammatory disorder driven by extensive molecular reprogramming. Despite significant bench research into its pathogenesis, translating these molecular discoveries into clinical practices that improv…

Haochan Wu,1,* Fangfang Shan,1,* Mengmeng Ye,1 Hui Zhou,1,2 Jie Jiao,3 Zhaoxia Zhong,4 Yibo Wu1,2 1Human Reproductive Medicine Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of China; 2Human Genetic and …

INTRODUCTION: Studies indicate that endometriosis (EMs) is associated with inflammation and metabolic abnormalities. The Remnant Cholesterol Inflammatory Index (RCII) concurrently reflects both inflammatory and metabolic status. However, th…

PurposeVaginal natural orifice transluminal endoscopic surgery (vNOTES) is an innovative minimally invasive procedure. The study aimed to evaluate whether vNOTES achieves non-inferior results compared to conventional laparoscopy in patients…

Thin endometrium is one of the main factors leading to infertility and miscarriage. The development of biomaterial technology and its clinical applications have shown good effects in promoting endometrial regeneration, improving blood flow,…

OBJECTIVES: To investigate the clinical characteristics of deep infiltrating endometriosis (DIE), summarize the experiences in its diagnosis and management, and identify potential peripheral blood indicators associated with the severity of …

Endometriosis is caused by the migration of endometrial cells to locations outside the uterine lining. Despite the increasing prevalence of endometriosis, there has been limited research on genetic effects, and its molecular mechanisms rema…

The microbiota of the female genital tract is crucial for reproductive health. This study aims to investigate the impact of the lower genital tract microbiota on in vitro fertilization and frozen embryo transfer (IVF-FET) outcomes. This stu…

IntroductionInflammation has been implicated in both reproduction and sleep; however, the relationships remain unclear, and conclusive evidence for genetic associations is lacking.MethodsThis study utilized the 2013-2020 National Health and…