Giordano FA

No ORCID on file · 2 papers in corpus · active 2020-2021
2021
Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma.
Investigational new drugs ·doi:10.1007/s10637-020-01037-7

Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified …

2020
Rho GTPases in Gynecologic Cancers: In-Depth Analysis toward the Paradigm Change from Reactive to Predictive, Preventive, and Personalized Medical Approach Benefiting the Patient and Healthcare.
Cancers ·doi:10.3390/cancers12051292

Rho guanosine triphospatases (GTPases) resemble a conserved family of GTP-binding proteins regulating actin cytoskeleton dynamics and several signaling pathways central for the cell. Rho GTPases create a so-called Ras-superfamily of GTPases…