Lea Duempelmann

No ORCID on file · 9 papers in corpus · active 2021-2026

Study types

  • article 4
  • other 3
  • preprint 2

Condition tags

  • endometriosis 8
  • dysmenorrhea 2
  • adenomyosis 2
  • chronic_pelvic_pain 1
  • endometrioma 1
  • die_deep_infiltrating 1
preprint 2026
Dienogest interrupts the chemokine signalling axis in endometriotic lesions with resistant signatures providing novel opportunities for personalised treatment.
·doi:10.21203/rs.3.rs-8096027/v1
other 2026
DuempelmannLea/endometriosis_endometrium_scRNA_atlas: Endometriosis-Related Alterations in the Endometrium revealed by Integrated Single-Cell and AI-Powered Approaches
·doi:10.5281/zenodo.19278463

Code to paper titled: Endometriosis-Related Alterations in the Endometrium revealed by Integrated Single-Cell and AI-Powered Approaches Paper author list: Lea Duempelmann, Shaoline Sheppard, Brett McKinnon, Angelo Duo, Jitka Skrabalova, Tho…

other 2026
DuempelmannLea/endometriosis_endometrium_scRNA_atlas: Endometriosis-Related Alterations in the Endometrium revealed by Integrated Single-Cell and AI-Powered Approaches
·doi:10.5281/zenodo.19278464

Code to paper titled: Endometriosis-Related Alterations in the Endometrium revealed by Integrated Single-Cell and AI-Powered Approaches Paper author list: Lea Duempelmann, Shaoline Sheppard, Brett McKinnon, Angelo Duo, Jitka Skrabalova, Tho…

article 2026
Endometriosis-related alterations in the endometrium revealed by integrated single-cell and AI-powered approaches
Nature communications ·doi:10.1038/s41467-026-73020-4

Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To address these issues, we generated a comprehensive single-cell atlas of endometrial tissue, comprising 466,371 cells from 35 endometriosis and 25 non-en…

article 2026
Endometriosis-related alterations in the endometrium revealed by integrated single-cell and AI-powered approaches.
·doi:10.48620/98305

Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To address these issues, we generated a comprehensive single-cell atlas of endometrial tissue, comprising 466,371 cells from 35 endometriosis and 25 non-en…

article 2025
The Swiss Endometriosis Database: a retrospective multicentre cohort study on pain levels and multimodal treatment needs of endometriosis patients
Swiss medical weekly ·doi:10.57187/s.3854

STUDY AIMS: This study aimed to deepen the understanding of endometriosis symptoms, types, and therapy recommendations for Swiss endometriosis patients in Swiss-certified endometriosis centres in 2022. METHODS: In this exploratory retrospec…

other 2024
Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis
International journal of molecular sciences ·doi:10.3390/ijms252313071

This study aimed to identify unique characteristics in the peripheral blood mononuclear cells (PBMCs) of endometriosis patients and develop a non-invasive early diagnostic tool. Using single-cell RNA sequencing (scRNA-seq), we constructed t…

preprint 2024
Tracing Endometriosis: Coupling deeply phenotyped, single-cell based Endometrial Differences and AI for disease pathology and prediction
·doi:10.1101/2024.08.09.606959

Abstract Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To address these issues, we generated the biggest single-cell atlas of endometrial tissue to date, comprising 466,371 cells from 35 endometriosis …

article 2021
Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2021.105943

Endometriosis is a common, estrogen-dependent disease, in which endometrial tissue grows in the peritoneal cavity. These lesions often express low levels of progesterone receptors (PR), which potentially play an important role in the insuff…