Liu Y

BACKGROUND: Early-life exposures may influence long-term reproductive health, but comprehensive population-based evidence remains limited. This study aimed to evaluate the associations between six early-life factors (long-term/recurrent ant…

OBJECTIVE: The aim of this study was to compare the therapeutic efficacy of integrating virtual reality technology with conventional pelvic floor rehabilitation therapy versus conventional therapy alone in postpartum women with myofascial p…

OBJECTIVE: Enhanced Recovery After Surgery (ERAS) protocols have been proven to optimize recovery in various surgical disciplines, including gynecologic surgery. However, their impact on laparoscopic hysterectomy for benign conditions remai…

Yiran Liu,1 Siyi Hua,1 Fang Wang,2 Caixia Zhou,3 Guiping Wan,1 Weiwei Tang11Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing…

Adenomyosis is a common gynecological disorder that causes heavy menstrual bleeding and chronic pelvic pain. Progestin-based therapy is widely used for long-term management, but irregular uterine bleeding frequently occurs and severely affe…

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disease worldwide, yet no pharmacological therapy has achieved regulatory approval. Flavonoids, plant-derived polyphenols encompass…

BACKGROUND: Non-neoplastic gynecological diseases substantially impact women of childbearing age (WCBA), contributing to global burden. Despite growing awareness, disparities in healthcare access remain widespread across regions and socioec…

Premature ovarian insufficiency (POI) is a significant clinical challenge leading to amenorrhea and infertility in young women. While its etiology is complex, recent research has highlighted aberrant protein glycosylation as a novel and cru…

Endometriosis (EMs) is a prevalent, estrogen-dependent gynecological disorder characterized by the ectopic implantation and proliferation of endometrial-like tissue outside the uterine cavity, affecting approximately 10% of reproductive-age…

Abstract Hypoxia, a state of reduced oxygen availability, drives endometrial disease progression by inducing cellular reprogramming that promotes inflammation, angiogenesis, and aberrant cell survival in endometriosis and endometrial cance…

BACKGROUND: Ovarian endometriomas impair ovarian reserve and fertility in women of reproductive age. Ethanol sclerotherapy is a fertility-preserving alternative to surgery. Nonetheless, predicting cumulative live birth rates after in vitro …

BACKGROUND: Among patients undergoing hysterectomy for benign indications, Black patients experience higher rates of perioperative complications across both abdominal and minimally invasive surgical routes. This disparity persists after adj…

BACKGROUND: IL20RB, interleukin 20 receptor subunit beta, functions as a cytokine receptor subunit coding gene and has been discovered to serve an essential function in human malignancies. However, the link between IL20RB expression, clinic…

INTRODUCTION: Retained products of conception (rPOC) are a common complication following early pregnancy loss (EPL) and may contribute to infertility and delays in subsequent fertility treatment. Oral contraceptive pills (OCPs) are frequent…

Endometriosis is an estrogen-dependent disorder characterized by chronic inflammation, immune dysregulation, and altered hormone metabolism. Although gut microbiota-derived metabolites have been implicated in shaping immune microenvironment…

BACKGROUND: Adenomyosis (AM) is frequently associated with compromised embryo implantation. The leukemia inhibitory factor (LIF)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for endometrial recepti…

Gynecological diseases represent a persistent global health burden. According to a WHO report, the global incidence of gynecological diseases exceeds 65%. Furthermore, over 90% of women suffer from gynecological issues to varying degrees. T…

The paradigm shift of lactate from a mere metabolic byproduct to a pleiotropic signaling molecule, coupled with the discovery of lactylation, provides a crucial framework for understanding how metabolic reprogramming drives systemic patholo…

Diminished ovarian reserve (DOR) is characterized by a decline in oocyte quantity and/or quality and represents a growing cause of female infertility, particularly among young women, yet its pathogenesis remains incompletely understood. Dis…

Endometriosis (EMS) is a common gynecological disease that seriously affects women's health and quality of life. However, the detailed dynamic cellular and molecular mechanisms underlying EMS pathogenesis remain largely unknown. This study …

BACKGROUND: Predicting in vitro fertilization (IVF) pregnancy outcomes is crucial for individualized decision-making. However, due to complex interactions among multiple factors, accurate manual integration and assessment are challenging. T…

Acute severe joint pain is a major symptom in gouty arthritis (GA), and its adequate treatment represents an unmet medical need. Mrgprb2, a specific mast cell receptor, has been implicated in the generation of chronic pain by mobilizing mas…

Unexplained recurrent pregnancy loss (URPL) represents a prevalent obstetric complication and remains a challenging condition with poorly understood genetic etiology. Through whole-exome sequencing of 94 URPL patients, we identified enriche…

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

Yike Liu The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, People’s Republic of ChinaCorrespondence: Yike Liu, Email [email protected]