Chen XY

Proper oocyte maturation is critical for female fertility, yet whether cuproptosis, a recently identified copper-dependent cell death pathway, affects meiotic maturation remains unknown. Here, we show that Cu(II)-elesclomol (ELC-Cu(II)) tre…

INTRODUCTION: Acute respiratory distress syndrome (ARDS) manifests as acute pulmonary inflammation associated with high mortality. While intermittent prone positioning for 12-16 h is an essential intervention in managing severe ARDS, clinic…

MicroRNA-17(miR-17) is a prototypical oncogenic miRNA that plays a central driving role in the initiation and progression of various malignant tumours (MT), including lymphoma, lung cancer, colorectal cancer (CRC), and breast cancer (BC). I…

OBJECTIVE: The aim of this study was to investigate the effects of SEPT9 on proliferation, migration, and apoptosis in endometriotic stromal cells and to explore the underlying mechanisms. METHODS: Immunohistochemistry and western blotting…

Ferroptosis is a novel form of programmed cell death characterized by iron-dependent lipid peroxidation (LPO). It has been widely demonstrated in the last years to play a crucial pathogenic role in ischemia-reperfusion injury (IRI). The pat…

BACKGROUND: Recurrent spontaneous abortion (RSA) is a multifactorial disease, the exact causes of which are still unknown. Environmental, maternal, and genetic factors have been shown to contribute to this condition. The aim of this study w…

BACKGROUND: Tenofovir disoproxil fumarate (TDF) is a prodrug of a nucleotide analogue. As an antiviral drug, TDF has been proposed in the first-line treatment of chronic hepatitis B (CHB). Qingzhong, a brand name of TDF, commercialized by J…

Epithelial-mesenchymal transition (EMT) plays a significant part in the pathogenesis of endometriosis by facilitating the migration and invasion abilities of cells. Integrin-linked kinase (ILK) increases the cell migration and invasion abil…

Melatonin confers protective effects on premature ovarian insufficiency (POI) induced by tripterygium glycosides (TG) by reducing oxidative stress. Silent information regulator 1 (SIRT1) signaling is found to be associated with the physiolo…