Fang Y

Deep infiltrating endometriosis (DIE) is a severe condition frequently linked to infertility, yet the optimal integration of surgery and assisted reproductive technology (ART) remains controversial. This study reports two cases of infertili…

BACKGROUND: Purinergic P2 receptors, which can be divided into ionotropic P2X receptors and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine nucleoside triphosphates and diphosphate. Based on the wide…

BACKGROUND: Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature o…

BACKGROUND: Insomnia is increasingly emerging as a significant concern in public health, with a longstanding emphasis on its relationship with overall well-being. Nevertheless, few research has been devoted to investigating the relationship…

Hanke Zhang, Yuqing Fang, Dan Luo, Yan-Hui Li Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, People’s Republic of ChinaCorrespondence: Ya…

PURPOSE: Endometriosis is a common chronic neuroinflammatory disease with a poorly understood pathogenesis. Molecular changes and specific immune cell infiltration in the eutopic endometrium are critical to disease progression. This study a…

Mercury, a prevalent heavy metal, negatively impacts oocyte maturation. However, the exact mechanism by which methylmercury chloride (MMC) affects this process remains elusive. The present study found that MMC administration triggered meiot…

BACKGROUND: The human endometrium is a regenerative tissue relying on stem/progenitor cells. Endometrial mesenchymal stem cells (eMSCs) are typically enriched using perivascular markers like CD140b and CD146. However, the identity of more p…

Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, leading to infertility. Elevated basal luteinizing hormone (bLH) levels in PC…

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and visceral fat but its implications for infertility risks and diagnostic value a…

RATIONALE: This study aims to explore the application of a WeChat-based telemedicine collaborative care model for managing the full disease cycle of a child with Type I congenital vaginal atresia complicated by megacolon. Given the complexi…

RATIONALE: Endometrial stromal sarcoma is an extremely rare mesenchymal neoplasm occurring in the extrauterine. Retroperitoneal endometrial stromal sarcoma with multiple pulmonary metastases, in particular, is extremely rare. PATIENT CONCE…

OBJECTIVE: The aim of this study was to enhance the precision of categorization of endometrial lesions in ultrasound images via a data enhancement framework based on deep learning (DL), through addressing diagnostic accuracy challenges, con…

Background: Ovarian cancer (OV) is a prevalent malignancy among gynecological tumors. Numerous metabolic pathways play a significant role in various human diseases, including malignant tumors. Our study aimed to develop a prognostic signatu…

OBJECTIVES: To compare the accuracy of transvaginal ultrasound (TVUS) with laparoscopy in detecting and characterizing uterosacral ligament (USL) nodules of deep infiltrative endometriosis (DIE) between patients with and without pouch of Do…

Hypoxia-inducible factor 1 alpha (HIF-1α) is a major molecular mediator of the hypoxic response. In the endometrium, local hypoxic conditions induced by hormonal fluctuations and endometrial vascular remodeling contribute to the production …

STUDY QUESTION: Which independent factors influence ICSI outcomes in patients with complete azoospermia factor c (AZFc) microdeletions? SUMMARY ANSWER: In patients with complete AZFc microdeletions, the sperm source, male LH, the type of i…

BACKGROUND: In-depth understanding of dynamic expression profiles of human granulosa cells (GCs) during follicular development will contribute to the diagnostic and targeted interventions for female infertility. However, genome-scale analys…

RESEARCH QUESTION: What are the metabolic characteristics of follicular fluid in patients with ovarian endometriosis undergoing IVF? DESIGN: This was an exploratory cohort study on endometriosis. In total, 19 infertile patients with ovaria…

BACKGROUND: Endometriosis is well known as a chronic inflammatory disease. The development of endometriosis is heavily influenced by the estrogen receptor β (ERβ), while NOD-like receptors (NLRs) family CARD domain-containing 5 (NLRC5) exhi…

Endometriosis (EMS) is a prevalent disease and the etiologies has not uniform. Microbiota is associated with human diseases. To delve into the relationship between EMS and microbiota, Ectopic (EM) and eutopic (EU) endometrial tissues, phary…

BACKGROUND: Premature ovarian insufficiency (POI) is an important cause of infertility characterized by the functional decline of the ovary. Granulosa cells (GCs) around oocytes are critical for folliculogenesis, and GC dysfunction is one o…

ObjectiveThe objective of this study was to examine the influence of repeated embryo implantation failures on pregnancy outcomes among patients under 40 years of age undergoing in vitro fertilization/intracytoplasmic sperm injection embryo …

Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-as…