Wen Z

BackgroundAs the global population ages, pancreatitis in older adults has become a public health issue. Nonetheless, detailed information on its global impact and changing patterns is limited. We sought to explore the epidemiological trends…

Endometriosis (EMs) is an estrogen-dependent, chronic inflammatory disorder characterized by immune microenvironment dysregulation, a critical factor in its pathogenesis. Despite existing therapies, limitations persist, highlighting the urg…

This study aimed to investigate the associations between a dietary index for gut microbiota (DI-GM), flavonoid intake, and female infertility, while exploring age-specific differences in these relationships to identify potential dietary str…

Abstract Uterine peristalsis involves spontaneous, mild contractions of the sub-endometrial layer in the nonpregnant uterus, playing a crucial role in menstruation and fertility. Disruptions in peristaltic patterns have been linked to cond…

Hu sheep are renowned for their adaptation to high-temperature, humid environments and their high fecundity. Despite serving as the founder species for sheep breeding in China, the genetic mechanisms underlying these desirable traits and th…

BACKGROUND: Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. METHODS: BPA target genes were retrieved from ChEMBL, DrugBank,…

Designing and standardizing drug formulations are crucial for ensuring the safety and efficacy of medications. Nanomedicine utilizes nano drug delivery systems and advanced nanodevices to address numerous critical medical challenges. Curren…

IntroductionThe addition of antagonists is mainly based on estrogen level and follicle size, while LH level has not received sufficient attention.In this study, LH Level on the antagonist administration day was used as the main research obj…

Throughout the menstrual cycle, spontaneous mild contractions in the inner layer of the uterine smooth muscle cause uterine peristalsis, which plays a critical role in normal menstruation and fertility. Disruptions in peristalsis patterns m…

BackgroundEpidemiological studies have shown that young women often suffer from primary dysmenorrhea (PD) which is a common cause that affects their routine work and quality of life. Chinese herbal medicine has been widely used for PD in Ch…

Kawasaki disease (KD) is an acute vasculitis of pediatric populations that may develop coronary artery aneurysms if untreated. It has been regarded as the principal cause of acquired heart disease in children of the developed countries. Int…

IntroductionPsoriasis vulgaris is a common skin disease characterized by persistent localized erythematous scaly plaques, typically on the elbows, knees, and scalp. It is an immune-abnormal disease that progresses slowly over a long period …

MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy. To facilitate the clinical cancer research, we proposed a network-based strategy to identify the…

BackgroundTo evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids.MethodsThis is a Multicenter randomized controlled trial. A total of 501 subjects with symptom…

OBJECTIVE: To investigate the expression of CD56 in endometrial samples from patients with adenomyosis and its relationship with menstrual cycle phase and severity of dysmenorrhea. STUDY DESIGN: 40 patients with histologically proved adeno…

Phosphatase and tensin homolog (PTEN) and protein phosphatase type 2A (PP2A) are negative modulators of PI3K/AKT/survivin signaling. To evaluate immunoexpression of PTEN, PP2A and survivin in adenomyosis, ectopic lesions from 28 patients wi…

Acute pancreatitis, a common necroinflammatory disease of the pancreas, remains an unsolved problem that is associated with significant morbidity and mortality. Intra-acinar cell activation of digestion enzymes triggers the events of acute …

Adenomyosis is a finding that is associated with dysmenorrhea and heavy menstrual bleeding, associated with PI3K/AKT signaling overactivity. To investigate the effect of metformin on the growth of eutopic endometrial stromal cells (ESCs) fr…

ObjectiveTo investigate the expression and potential roles of interleukin-10 receptor 1 (IL-10R1) and interleukin-10 receptor 2 (IL-10R2) in adenomyosis.Study designThis prospective study examined 33 women with histologically proven adenomy…

CagA of Helicobacter pylori is a bacterium-derived oncogenic protein closely associated with the development of gastric cancers. MicroRNAs (miRNAs) are a class of widespread non-coding RNAs, many of which are involved in cell growth, cell d…

OBJECTIVE: To explore the stroma-epithelium interactions in endometriosis and to identify the possible signalling pathways involved in this cross-talk. DESIGN: Laboratory study via primary cultured endometrial stromal and epithelial cells.…

UnlabelledThe objective of this study was to explore the mechanism of phosphatase and tensin homolog (PTEN) loss in endometriosis. We found that aberrant PTEN expression and mitogen-activated protein kinases (MAPK)/ERK, phosphoinositide 3-k…

In normal endometrium, stromal factors regulate the growth of epithelial cells. However, epithelial cells in endometriotic lesions display increased proliferation and decreased apoptosis. This work tested the hypothesis that in endometriosi…

OBJECTIVE: To investigate the expression of interleukin-10 (IL-10) in adenomyosis. DESIGN: Laboratory study using human tissue. SETTING: University hospital. PATIENT(S): Thirty-four patients with adenomyosis and 30 women without adenomyo…

BackgroundSeveral different microarray platforms are available for measuring gene expression. There are disagreements within the microarray scientific community for intra- and inter-platform consistency of these platforms. Both high and low…