Rajesh Kumar Jha

No ORCID on file · 8 papers in corpus · active 2018-2025

Study types

  • article 5
  • other 2
  • erratum 1

Condition tags

  • endometriosis 8
  • infertility 2
article 2025
MCP-1 promotes ILK phosphorylation at Ser246 during endometriosis development and affects the pregnancy outcome
Molecular human reproduction ·doi:10.1093/molehr/gaaf004

In women with endometriosis, monocyte chemoattractant protein 1 (MCP-1) or chemokine (C-C motif) ligand 2 (CCL2) is elevated in serum, peritoneal fluid, and endometriotic lesions, though its exact role in endometriosis is still unknown. The…

other 2025
PARP-2 acts on ILK signaling and pharmacological targeting of PARP-2 ameliorate endometriosis in a mouse model
Biochemical and biophysical research communications ·doi:10.1016/j.bbrc.2025.151509

Endometriosis, an endocrine disorder in reproductive-aged women with an occurrence of ∼10 %, gives rise to inflammation, pelvic pain, menstrual irregularity, infertility, etc. One study demonstrated the elevated plasma level of PARP during …

erratum 2024
Corrigendum to "MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis" [Life Sci. 353 (2024) 122902]
Life sciences ·doi:10.1016/j.lfs.2024.123246
article 2024
MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis
Life sciences ·doi:10.1016/j.lfs.2024.122902

AIMS: MCP-1 has been shown to be elevated in endometriosis. ILK functions in several cellular events and interacts with MCP-1-signaling. In the current study, we evaluated the role of MCP-1-ILK signaling in human endometriotic cell's (Hs832…

other 2023
Stomatin-like Protein-2 Promotes Aggregation, Colonization and Migration of Endometriotic Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-022-01139-y

Endometriosis is a chronic gynecological disease in women of childbearing age, which leads to infertility with risk of endometrial and ovarian cancer. The pathogenesis of endometriosis is poorly understood, and cure/treatment for it is not …

article 2021
Targeted inhibition of TAK1 abrogates TGFβ1 non-canonical signaling axis, NFκB/Smad7 inhibiting human endometriotic cells proliferation and inducing cell death involving autophagy
Cytokine ·doi:10.1016/j.cyto.2021.155700
article 2019
SAT-197 Functional Cross-Talk Between MCP-1 and Integrin Linked Kinase Is Required for Endometriosis Disease Progression
·doi:10.1210/js.2019-sat-197

Development of painful invasive endometriotic lesions is usually a combined function of the chronic inflammation and active sequential cellular events such as migration, cell adhesion, proliferation, colonization, and invasion in endometrio…

article 2018
A high level of TGF-B1 promotes endometriosis development via cell migration, adhesiveness, colonization, and invasiveness†
Biology of reproduction ·doi:10.1093/biolre/ioy242

Endometriosis is a prevalent gynecological disorder that eventually gives rise to painful invasive lesions. Increased levels of transforming growth factor-beta 1 (TGF-B1) have been reported in endometriosis. However, details of the effects …