Owen GI

No ORCID on file · 2 papers in corpus · active 2008-2014

Study types

  • review 1

Condition tags

  • endometriosis 1
  • infertility 1
review 2014
2-methoxyestradiol and disorders of female reproductive tissues
Hormones & cancer ·doi:10.1007/s12672-014-0181-2

2-Methoxyestradiol (2ME) is an endogenous metabolite of 17β-estradiol. Once thought of as a mere degradation product, 2ME has gained attention as an important component of reproductive physiology and as a therapeutic agent in reproductive p…

2008
2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts.
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719108324171

ObjectiveThe estrogen metabolite 2-methoxyestradiol has shown antitumorigenic action in some epithelial tumors. In the present work we investigate its effects in ovarian cancer used alone or in combination with other apoptotic-inducing reag…